Naloxone benzoylhydrazone | CAS# 119630-94-3 | Biochemical

MedKoo Cat#: 577947 | Name: Naloxone benzoylhydrazone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Naloxone benzoylhydrazone is a kappa 3 opioid agonist.

Chemical Structure

Naloxone benzoylhydrazone

CAS#119630-94-3

Theoretical Analysis

MedKoo Cat#: 577947

Name: Naloxone benzoylhydrazone

CAS#: 119630-94-3

Chemical Formula: C26H27N3O4

Exact Mass: 445.2002

Molecular Weight: 445.52

Elemental Analysis: C, 70.09; H, 6.11; N, 9.43; O, 14.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Naloxone benzoylhydrazone; Nalbzoh

IUPAC/Chemical Name

Benzoic acid, ((5alpha)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene)hydrazide

InChi Key

AKXCFAYOTIEFOH-XTNAHFASSA-N

InChi Code

InChI=1S/C26H27N3O4/c1-2-13-29-14-12-25-21-17-8-9-19(30)22(21)33-23(25)18(10-11-26(25,32)20(29)15-17)27-28-24(31)16-6-4-3-5-7-16/h2-9,20,23,30,32H,1,10-15H2,(H,28,31)/b27-18+/t20-,23+,25+,26-/m1/s1

SMILES Code

Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)\C(=N\NC(=O)c6ccccc6)\CC[C@@]35O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 445.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Paul D, Levison JA, Howard DH, Pick CG, Hahn EF, Pasternak GW. Naloxone benzoylhydrazone (NalBzoH) analgesia. J Pharmacol Exp Ther. 1990 Nov;255(2):769-74. PMID: 2173757. 2. Koch JE, Pasternak GW, Arjune D, Bodnar RJ. Naloxone benzoylhydrazone, a kappa 3 opioid agonist, stimulates food intake in rats. Brain Res. 1992 May 29;581(2):311-4. doi: 10.1016/0006-8993(92)90723-m. PMID: 1327401. 3. Olianas MC, Concas D, Onali P. Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br J Pharmacol. 2006 Feb;147(4):360-70. doi: 10.1038/sj.bjp.0706601. PMID: 16402046; PMCID: PMC1616995.