MP-412 (AV-412) is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR (L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib.
MedKoo Cat#: 125906
Name: AV-412 free base
CAS#: 451492-95-8 (free base)
Chemical Formula: C27H28ClFN6O
Exact Mass: 506.1997
Molecular Weight: 507.01
Elemental Analysis: C, 63.96; H, 5.57; Cl, 6.99; F, 3.75; N, 16.58; O, 3.16
The following data is based on the product molecular weight 507.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
