MedKoo Cat#: 464616 | Name: V-10367

Description:

WARNING: This product is for research use only, not for human or veterinary use.

V-10367 is a non-immunosuppressive immunophilins ligand, demonstrating enhanced neuroregeneration in the peripheral nervous system and CNS.

Chemical Structure

V-10367
V-10367
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464616

Name: V-10367

CAS#: unknown

Chemical Formula: C35H42N2O7

Exact Mass: 602.2992

Molecular Weight: 602.73

Elemental Analysis: C, 69.75; H, 7.02; N, 4.65; O, 18.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
V-10367; V10367; V 10367; V-10,367; V10,367; V 10,367;
IUPAC/Chemical Name
1-phenyl-7-(pyridin-3-yl)heptan-4-yl (2S)-1-(2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxylate
InChi Key
FPYPCCMYCGEALM-XIJSCUBXSA-N
InChi Code
InChI=1S/C35H42N2O7/c1-41-30-22-27(23-31(42-2)33(30)43-3)32(38)34(39)37-21-8-7-19-29(37)35(40)44-28(17-9-14-25-12-5-4-6-13-25)18-10-15-26-16-11-20-36-24-26/h4-6,11-13,16,20,22-24,28-29H,7-10,14-15,17-19,21H2,1-3H3/t28?,29-/m0/s1
SMILES Code
O=C([C@H]1N(C(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=O)CCCC1)OC(CCCC3=CC=CN=C3)CCCC4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 602.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Toll EC, Seifalian AM, Birchall MA. The role of immunophilin ligands in nerve regeneration. Regen Med. 2011 Sep;6(5):635-52. doi: 10.2217/rme.11.43. PMID: 21916598. 2: Johnston TH, Brotchie JM. Drugs in development for Parkinson's disease. Curr Opin Investig Drugs. 2004 Jul;5(7):720-6. PMID: 15298067. 3: Rosenstiel P, Schramm P, Isenmann S, Brecht S, Eickmeier C, Bürger E, Herdegen T, Sievers J, Lucius R. Differential effects of immunophilin-ligands (FK506 and V-10,367) on survival and regeneration of rat retinal ganglion cells in vitro and after optic nerve crush in vivo. J Neurotrauma. 2003 Mar;20(3):297-307. doi: 10.1089/089771503321532888. PMID: 12820684. 4: Klettner A, Herdegen T. The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response. Br J Pharmacol. 2003 Mar;138(5):1004-12. doi: 10.1038/sj.bjp.0705132. PMID: 12642403; PMCID: PMC1573741. 5: Kupina NC, Detloff MR, Dutta S, Hall ED. Neuroimmunophilin ligand V-10,367 is neuroprotective after 24-hour delayed administration in a mouse model of diffuse traumatic brain injury. J Cereb Blood Flow Metab. 2002 Oct;22(10):1212-21. doi: 10.1097/01.wbc.0000037994.34930.bc. PMID: 12368660. 6: Klettner A, Baumgrass R, Zhang Y, Fischer G, Bürger E, Herdegen T, Mielke K. The neuroprotective actions of FK506 binding protein ligands: neuronal survival is triggered by de novo RNA synthesis, but is independent of inhibition of JNK and calcineurin. Brain Res Mol Brain Res. 2001 Dec 16;97(1):21-31. doi: 10.1016/s0169-328x(01)00286-8. PMID: 11744159. 7: Shefner JM, Brown RH Jr, Cole D, Chaturvedi P, Schoenfeld D, Pastuszak K, Matthews R, Upton-Rice M, Cudkowicz ME. Effect of neurophilin ligands on motor units in mice with SOD1 ALS mutations. Neurology. 2001 Nov 27;57(10):1857-61. doi: 10.1212/wnl.57.10.1857. PMID: 11723276.