MedKoo Cat#: 128824 | Name: INT-131
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

INT-131 is a partial agonist of peroxisome proliferator-activated receptor γ (PPARγ).

Chemical Structure

INT-131
INT-131
CAS#315224-26-1

Theoretical Analysis

MedKoo Cat#: 128824

Name: INT-131

CAS#: 315224-26-1

Chemical Formula: C21H12Cl4N2O3S

Exact Mass: 511.9323

Molecular Weight: 514.20

Elemental Analysis: C, 49.05; H, 2.35; Cl, 27.58; N, 5.45; O, 9.33; S, 6.23

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 650.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
INT-131; INT 131; INT131
IUPAC/Chemical Name
2,4-dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide
InChi Key
NMRWDFUZLLQSBN-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H
SMILES Code
O=S(NC1=CC(Cl)=C(C(Cl)=C1)OC2=CN=C3C=CC=CC3=C2)(C4=CC=C(Cl)C=C4Cl)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 514.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Taygerly, J.P., McGee, L.R., Rubenstein, S.M., et al. Discovery of INT131: A selective PPARγ modulator that enhances insulin sensitivity. Bioorg. Med. Chem. 21(4), 979-992 (2013). 2. Omeragic, A., Saikali, M.F., Currier, S., et al. Selective peroxisome proliferator-activated receptor-gamma modulator, INT131 exhibits anti-inflammatory effects in an EcoHIV mouse model. FASEB J. 34(2), 1996-2010 (2020).