Valecobulin HCl | beta-tubulin polymerization inhibitor | CAS#1240321-53-2

MedKoo Cat#: 125810 | Name: Valecobulin HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Valecobulin is an anti-neoplastic beta-tubulin polymerization inhibitor. Tubulin polymerization inhibitors may be useful in inducing cancer cell apoptosis.

Chemical Structure

Valecobulin HCl

CAS#1240321-53-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 125810

Name: Valecobulin HCl

CAS#: 1240321-53-2 (HCl)

Chemical Formula: C26H29ClN6O5S

Exact Mass: 572.1600

Molecular Weight: 573.07

Elemental Analysis: C, 54.49; H, 5.10; Cl, 6.19; N, 14.67; O, 13.96; S, 5.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

1240321-53-2 (HCl) 1188371-47-2 (free base)

Synonym

CKD-516; 1240321-53-2; UNII-2J9QE0TM5I; Valecobulin (hydrochloride); Valecobulin hydrochloride; Valecobulin HCl

IUPAC/Chemical Name

N-(4-(3-(1H-1,2,4-triazol-1-yl)-4-(3,4,5-trimethoxybenzoyl)phenyl)thiazol-2-yl)-2-amino-3-methylbutanamide hydrochloride

InChi Key

FIAUXCMEQTWLQZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H28N6O5S.ClH/c1-14(2)22(27)25(34)31-26-30-18(11-38-26)15-6-7-17(19(8-15)32-13-28-12-29-32)23(33)16-9-20(35-3)24(37-5)21(10-16)36-4;/h6-14,22H,27H2,1-5H3,(H,30,31,34);1H

SMILES Code

CC(C)C(C(=O)NC1=NC(=CS1)C2=CC(=C(C=C2)C(=O)C3=CC(=C(C(=C3)OC)OC)OC)N4C=NC=N4)N.Cl

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 573.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mahale S, Bharate SB, Manda S, Joshi P, Jenkins PR, Vishwakarma RA, Chaudhuri B. Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerization. Cell Death Dis. 2015 May 7;6:e1743. doi: 10.1038/cddis.2015.96. PubMed PMID: 25950473; PubMed Central PMCID: PMC4669722. 2: Saha A, Mohapatra S, Kurkute P, Jana B, Mondal P, Bhunia D, Ghosh S, Ghosh S. Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells. Chem Commun (Camb). 2015 Feb 11;51(12):2249-52. doi: 10.1039/c4cc09390a. PubMed PMID: 25567764.