Synonym
Quinidine hydrochloride; EINECS 216-792-8; Quinidine HCl
IUPAC/Chemical Name
(1S)-(6-methoxyquinolin-4-yl)((2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol hydrochloride
InChi Key
LBSFSRMTJJPTCW-VJAUXQICSA-N
InChi Code
InChI=1S/C20H24N2O2.ClH/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H/t13-,14-,19+,20-;/m0./s1
SMILES Code
COc(cc1)cc2c1nccc2[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
360.88
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Vitali Serdoz L, Rittger H, Furlanello F, Bastian D. Quinidine-A legacy within the modern era of antiarrhythmic therapy. Pharmacol Res. 2019 Jun;144:257-263. doi: 10.1016/j.phrs.2019.04.028. Epub 2019 Apr 23. PMID: 31026503.
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7: Luo C, Whittaker DG, Liu T, Wang K, Li Y, He Y, Zhang H. Pharmacotherapeutic Effects of Quinidine on Short QT Syndrome by Using Purkinje-Ventricle Model: A Simulation Study. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:2856-2859. doi: 10.1109/EMBC.2019.8857134. PMID: 31946488.
8: Ochs HR, Greenblatt DJ, Woo E. Clinical pharmacokinetics of quinidine. Clin Pharmacokinet. 1980 Mar-Apr;5(2):150-68. doi: 10.2165/00003088-198005020-00003. PMID: 6988137.
9: Che Z, Yang J, Sun D, Tian Y, Liu S, Lin X, Jiang J, Chen G. Synthesis of Novel (9S)-Acyloxy Derivatives of Quinidine and Dihydroquinidine as Insecticidal Agents. Chem Biodivers. 2020 Apr;17(4):e1900696. doi: 10.1002/cbdv.201900696. Epub 2020 Mar 30. PMID: 32134169.
10: Malcolm AD, David GK. Quinidine in cardiology. Acta Leiden. 1987;55:87-98. PMID: 3321844.