MedKoo Cat#: 412828 | Name: Quinidine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quinidine hydrochloride is the salt form of Qunidine, and Antiarrhythmic and Anti-parasite. It can treat certain kinds of irregular heartbeats (arrhythmias). It can also treat malaria.

Chemical Structure

Quinidine hydrochloride
Quinidine hydrochloride
CAS#1668-99-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 412828

Name: Quinidine hydrochloride

CAS#: 1668-99-1 (HCl)

Chemical Formula: C20H25ClN2O2

Exact Mass: 360.1605

Molecular Weight: 360.88

Elemental Analysis: C, 66.56; H, 6.98; Cl, 9.82; N, 7.76; O, 8.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Quinidine hydrochloride; EINECS 216-792-8; Quinidine HCl
IUPAC/Chemical Name
(1S)-(6-methoxyquinolin-4-yl)((2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol hydrochloride
InChi Key
LBSFSRMTJJPTCW-VJAUXQICSA-N
InChi Code
InChI=1S/C20H24N2O2.ClH/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H/t13-,14-,19+,20-;/m0./s1
SMILES Code
COc(cc1)cc2c1nccc2[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 360.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bozic B, Uzelac TV, Kezic A, Bajcetic M. The Role of Quinidine in the Pharmacological Therapy of Ventricular Arrhythmias 'Quinidine'. Mini Rev Med Chem. 2018;18(6):468-475. doi: 10.2174/1389557517666170707110450. PMID: 28685701. 2: Vitali Serdoz L, Rittger H, Furlanello F, Bastian D. Quinidine-A legacy within the modern era of antiarrhythmic therapy. Pharmacol Res. 2019 Jun;144:257-263. doi: 10.1016/j.phrs.2019.04.028. Epub 2019 Apr 23. PMID: 31026503. 3: Mason JW, Hondeghem LM. Quinidine. Ann N Y Acad Sci. 1984;432:162-76. doi: 10.1111/j.1749-6632.1984.tb14518.x. PMID: 6395759. 4: Yang F, Hanon S, Lam P, Schweitzer P. Quinidine revisited. Am J Med. 2009 Apr;122(4):317-21. doi: 10.1016/j.amjmed.2008.11.019. Epub 2009 Feb 25. PMID: 19249010. 5: Kay CF. Quinidine--a re-evaluation. Med Clin North Am. 1966 Sep;50(5):1221-30. PMID: 5339487. 6: BAROODY WG, BAROODY NB. Quinidine. Med Times. 1960 Aug;88:962-5. PMID: 13797001. 7: Luo C, Whittaker DG, Liu T, Wang K, Li Y, He Y, Zhang H. Pharmacotherapeutic Effects of Quinidine on Short QT Syndrome by Using Purkinje-Ventricle Model: A Simulation Study. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:2856-2859. doi: 10.1109/EMBC.2019.8857134. PMID: 31946488. 8: Ochs HR, Greenblatt DJ, Woo E. Clinical pharmacokinetics of quinidine. Clin Pharmacokinet. 1980 Mar-Apr;5(2):150-68. doi: 10.2165/00003088-198005020-00003. PMID: 6988137. 9: Che Z, Yang J, Sun D, Tian Y, Liu S, Lin X, Jiang J, Chen G. Synthesis of Novel (9S)-Acyloxy Derivatives of Quinidine and Dihydroquinidine as Insecticidal Agents. Chem Biodivers. 2020 Apr;17(4):e1900696. doi: 10.1002/cbdv.201900696. Epub 2020 Mar 30. PMID: 32134169. 10: Malcolm AD, David GK. Quinidine in cardiology. Acta Leiden. 1987;55:87-98. PMID: 3321844.