Valecobulin | CAS# 1188371-47-2 | beta-tubulin polymerization inhibitor

MedKoo Cat#: 572154 | Name: Valecobulin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Valecobulin is an anti-neoplastic beta-tubulin polymerization inhibitor. Tubulin polymerization inhibitors may be useful in inducing cancer cell apoptosis.

Chemical Structure

Valecobulin

CAS#1188371-47-2 (free base)

Theoretical Analysis

MedKoo Cat#: 572154

Name: Valecobulin

CAS#: 1188371-47-2 (free base)

Chemical Formula: C26H28N6O5S

Exact Mass: 536.1842

Molecular Weight: 536.61

Elemental Analysis: C, 58.20; H, 5.26; N, 15.66; O, 14.91; S, 5.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1240321-53-2 (HCl) 1188371-47-2 (free base)

Synonym

Valecobulin

IUPAC/Chemical Name

(2S)-2-amino-3-methyl-N-{4-[3-(1H-1,2,4-triazol-1-yl)- 4-(3,4,5-trimethoxybenzoyl)phenyl]-1,3-thiazol- 2-yl}butanamide

InChi Key

UKKRUIXIDCWALA-QFIPXVFZSA-N

InChi Code

InChI=1S/C26H28N6O5S/c1-14(2)22(27)25(34)31-26-30-18(11-38-26)15-6-7-17(19(8-15)32-13-28-12-29-32)23(33)16-9-20(35-3)24(37-5)21(10-16)36-4/h6-14,22H,27H2,1-5H3,(H,30,31,34)/t22-/m0/s1

SMILES Code

CC(C)[C@H](N)C(NC1=NC(C2=CC=C(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C(N4N=CN=C4)=C2)=CS1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 536.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mahale S, Bharate SB, Manda S, Joshi P, Jenkins PR, Vishwakarma RA, Chaudhuri B. Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerization. Cell Death Dis. 2015 May 7;6:e1743. doi: 10.1038/cddis.2015.96. PubMed PMID: 25950473; PubMed Central PMCID: PMC4669722. 2: Saha A, Mohapatra S, Kurkute P, Jana B, Mondal P, Bhunia D, Ghosh S, Ghosh S. Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells. Chem Commun (Camb). 2015 Feb 11;51(12):2249-52. doi: 10.1039/c4cc09390a. PubMed PMID: 25567764.