Synonym
Ritobegron ethyl; (-)-Ritobegron ethyl; Ritobegron ethyl, (-)-; KUC-7483 free base; UNII-E89L9L8KFH
IUPAC/Chemical Name
ethyl 2-(4-(2-(((1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)amino)ethyl)-2,5-dimethylphenoxy)acetate
InChi Key
SLXOKVKOBXCWCK-SBUREZEXSA-N
InChi Code
InChI=1S/C23H31NO5/c1-5-28-22(26)14-29-21-13-15(2)19(12-16(21)3)10-11-24-17(4)23(27)18-6-8-20(25)9-7-18/h6-9,12-13,17,23-25,27H,5,10-11,14H2,1-4H3/t17-,23-/m0/s1
SMILES Code
CCOC(=O)COC1=C(C)C=C(CCN[C@@H](C)[C@H](O)C2=CC=C(O)C=C2)C(C)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
401.50
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Abe Y, Ota E, Endo T, Murakami M, Kobayashi M. Absorption, disposition,
metabolism, and excretion of ritobegron (KUC-7483), a novel selective
β3-adrenoceptor agonist, in rats. Pharmazie. 2014 Dec;69(12):881-8. PubMed PMID:
25951660.
2: Maruyama I, Goi Y, Tatemichi S, Maruyama K, Hoyano Y, Yamazaki Y, Kusama H.
Bladder selectivity of the novel β₃-agonist ritobegron (KUC-7483) explored by in
vitro and in vivo studies in the rat. Naunyn Schmiedebergs Arch Pharmacol. 2012
Aug;385(8):845-52. doi: 10.1007/s00210-012-0755-x. Epub 2012 May 3. PubMed PMID:
22552730.
3: Maruyama I, Tatemichi S, Goi Y, Maruyama K, Hoyano Y, Yamazaki Y, Kusama H.
Effects of ritobegron (KUC-7483), a novel selective β3-adrenoceptor agonist, on
bladder function in cynomolgus monkey. J Pharmacol Exp Ther. 2012
Jul;342(1):163-8. doi: 10.1124/jpet.112.191783. Epub 2012 Apr 16. PubMed PMID:
22511202.
4: Maruyama I, Yonekubo S, Tatemichi S, Maruyama K, Hoyano Y, Yamazaki Y, Kusama
H. Effects of ritobegron (KUC-7483), a novel β3-adrenoceptor agonist, on both rat
bladder function following partial bladder outlet obstruction and on rat salivary
secretion: a comparison with the effects of tolterodine. J Smooth Muscle Res.
2012;48(5-6):115-24. PubMed PMID: 23538508.
