Synonym
KUC-7483; KUC 7483; KUC7483; Ritobegron; Ritobegron HCl; Ritobegron hydrochloride; brand name: Myrbetriq.
IUPAC/Chemical Name
ethyl 2-(4-(2-(((1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)amino)ethyl)-2,5-dimethylphenoxy)acetate hydrochloride
InChi Key
SDZAMDXEQUMDBE-DQFHVVJASA-N
InChi Code
InChI=1S/C23H31NO5.ClH/c1-5-28-22(26)14-29-21-13-15(2)19(12-16(21)3)10-11-24-17(4)23(27)18-6-8-20(25)9-7-18;/h6-9,12-13,17,23-25,27H,5,10-11,14H2,1-4H3;1H/t17-,23-;/m0./s1
SMILES Code
O=C(OCC)COC1=CC(C)=C(CCN[C@@H](C)[C@H](O)C2=CC=C(O)C=C2)C=C1C.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
437.96
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Abe Y, Ota E, Endo T, Murakami M, Kobayashi M. Absorption, disposition,
metabolism, and excretion of ritobegron (KUC-7483), a novel selective
β3-adrenoceptor agonist, in rats. Pharmazie. 2014 Dec;69(12):881-8. PubMed PMID:
25951660.
2: Maruyama I, Goi Y, Tatemichi S, Maruyama K, Hoyano Y, Yamazaki Y, Kusama H.
Bladder selectivity of the novel β₃-agonist ritobegron (KUC-7483) explored by in
vitro and in vivo studies in the rat. Naunyn Schmiedebergs Arch Pharmacol. 2012
Aug;385(8):845-52. doi: 10.1007/s00210-012-0755-x. Epub 2012 May 3. PubMed PMID:
22552730.
3: Maruyama I, Tatemichi S, Goi Y, Maruyama K, Hoyano Y, Yamazaki Y, Kusama H.
Effects of ritobegron (KUC-7483), a novel selective β3-adrenoceptor agonist, on
bladder function in cynomolgus monkey. J Pharmacol Exp Ther. 2012
Jul;342(1):163-8. doi: 10.1124/jpet.112.191783. Epub 2012 Apr 16. PubMed PMID:
22511202.
4: Maruyama I, Yonekubo S, Tatemichi S, Maruyama K, Hoyano Y, Yamazaki Y, Kusama
H. Effects of ritobegron (KUC-7483), a novel β3-adrenoceptor agonist, on both rat
bladder function following partial bladder outlet obstruction and on rat salivary
secretion: a comparison with the effects of tolterodine. J Smooth Muscle Res.
2012;48(5-6):115-24. PubMed PMID: 23538508.
