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MedKoo Cat#: 464669 | Name: Enrofloxacin-d5
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Enrofloxacin-d5 is intended for use as an internal standard for the quantification of enrofloxacin by GC- or LC-MS. Enrofloxacin is a fluoroquinolone antibiotic. It is active against panels of Campylobacter, E. coli, and Salmonella isolates (mean MIC50s = 0.06, 0.5, and 0.03 µg/ml, respectively). It is also active against equine isolates of L. intracellularis (MICs = 0.125-0.5 µg/ml). Enrofloxacin inhibits bacterial DNA gyrase. In vivo, enrofloxacin (10 mg/kg) increases survival in a mouse model of enteropathogenic E. coli-induced sepsis. Formulations containing enrofloxacin have been used in the treatment of veterinary bacterial infections.

Chemical Structure

Enrofloxacin-d5
Enrofloxacin-d5
CAS#1173021-92-5

Theoretical Analysis

MedKoo Cat#: 464669

Name: Enrofloxacin-d5

CAS#: 1173021-92-5

Chemical Formula: C19H17D5FN3O3

Exact Mass: 364.1959

Molecular Weight: 364.43

Elemental Analysis: C, 62.62; H, 7.47; F, 5.21; N, 11.53; O, 13.17

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 850.00 2 Weeks
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Related CAS #
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Synonym
Enrofloxacin-d5; Enrofloxacin d5; Enrofloxacine-d5; CFPQ-d5; BAY-Vp 2674-d5; ENR-d5; ENR d5;
IUPAC/Chemical Name
1-cyclopropyl-7-(4-(ethyl-d5)piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
InChi Key
SPFYMRJSYKOXGV-ZBJDZAJPSA-N
InChi Code
InChI=1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)/i1D3,2D2
SMILES Code
O=C1C2=CC(F)=C(C=C2N(C=C1C(O)=O)C3CC3)N4CCN(C([2H])(C([2H])([2H])[2H])[2H])CC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 10.0 27.44
DMF:PBS (pH 7.2) (1:1) 0.5 1.37
DMSO 1.0 2.74
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 364.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hassan MM, El Zowalaty ME, Lundkvist Å, Järhult JD, Khan Nayem MR, Tanzin AZ, Badsha MR, Khan SA, Ashour HM. Residual antimicrobial agents in food originating from animals. Trends Food Sci Technol. 2021 May;111:141-150. doi: 10.1016/j.tifs.2021.01.075. Epub 2021 Feb 3. PMID: 33746363; PMCID: PMC7953985. 2: Khademi F, Sahebkar A. Prevalence of Fluoroquinolone-Resistant Campylobacter Species in Iran: A Systematic Review and Meta-Analysis. Int J Microbiol. 2020 Oct 30;2020:8868197. doi: 10.1155/2020/8868197. PMID: 33488728; PMCID: PMC7803110. 3: Khusro A, Aarti C, Buendía-Rodriguez G, Arasu MV, Al-Dhabi NA, Barbabosa- Pliego A. Adverse Effect of Antibiotics Administration on Horse Health: An Overview. J Equine Vet Sci. 2021 Feb;97:103339. doi: 10.1016/j.jevs.2020.103339. Epub 2020 Dec 2. PMID: 33478757. 4: Delghandi MR, El-Matbouli M, Menanteau-Ledouble S. Renibacterium salmoninarum-The Causative Agent of Bacterial Kidney Disease in Salmonid Fish. Pathogens. 2020 Oct 15;9(10):845. doi: 10.3390/pathogens9100845. PMID: 33076564; PMCID: PMC7602803. 5: Huang F, An Z, Moran MJ, Liu F. Recognition of typical antibiotic residues in environmental media related to groundwater in China (2009-2019). J Hazard Mater. 2020 Nov 15;399:122813. doi: 10.1016/j.jhazmat.2020.122813. Epub 2020 May 29. PMID: 32937691. 6: Li Z, Li M, Zhang Z, Li P, Zang Y, Liu X. Antibiotics in aquatic environments of China: A review and meta-analysis. Ecotoxicol Environ Saf. 2020 Aug;199:110668. doi: 10.1016/j.ecoenv.2020.110668. Epub 2020 May 18. PMID: 32438219. 7: Ghirardini A, Grillini V, Verlicchi P. A review of the occurrence of selected micropollutants and microorganisms in different raw and treated manure - Environmental risk due to antibiotics after application to soil. Sci Total Environ. 2020 Mar 10;707:136118. doi: 10.1016/j.scitotenv.2019.136118. Epub 2019 Dec 15. PMID: 31881518. 8: Ahadi H, Emami S. Modification of 7-piperazinylquinolone antibacterials to promising anticancer lead compounds: Synthesis and in vitro studies. Eur J Med Chem. 2020 Feb 1;187:111970. doi: 10.1016/j.ejmech.2019.111970. Epub 2019 Dec 15. PMID: 31881454. 9: Rusch M, Spielmeyer A, Zorn H, Hamscher G. Degradation and transformation of fluoroquinolones by microorganisms with special emphasis on ciprofloxacin. Appl Microbiol Biotechnol. 2019 Sep;103(17):6933-6948. doi: 10.1007/s00253-019-10017-8. Epub 2019 Jul 22. PMID: 31332486. 10: Makielski K, Cullen J, O'Connor A, Jergens AE. Narrative review of therapies for chronic enteropathies in dogs and cats. J Vet Intern Med. 2019 Jan;33(1):11-22. doi: 10.1111/jvim.15345. Epub 2018 Dec 6. PMID: 30523666; PMCID: PMC6335544. 11: Mehlhorn A, Rahimi P, Joseph Y. Aptamer-Based Biosensors for Antibiotic Detection: A Review. Biosensors (Basel). 2018 Jun 11;8(2):54. doi: 10.3390/bios8020054. PMID: 29891818; PMCID: PMC6023021. 12: Nhung NT, Chansiripornchai N, Carrique-Mas JJ. Antimicrobial Resistance in Bacterial Poultry Pathogens: A Review. Front Vet Sci. 2017 Aug 10;4:126. doi: 10.3389/fvets.2017.00126. PMID: 28848739; PMCID: PMC5554362. 13: Govendir M. Review of some pharmacokinetic and pharmacodynamic properties of anti-infective medicines administered to the koala (Phascolarctos cinereus). J Vet Pharmacol Ther. 2018 Feb;41(1):1-10. doi: 10.1111/jvp.12435. Epub 2017 Jul 13. PMID: 28703410. 14: Fu H, Li X, Wang J, Lin P, Chen C, Zhang X, Suffet IHM. Activated carbon adsorption of quinolone antibiotics in water: Performance, mechanism, and modeling. J Environ Sci (China). 2017 Jun;56:145-152. doi: 10.1016/j.jes.2016.09.010. Epub 2016 Oct 26. PMID: 28571850. 15: Balakrishna K, Rath A, Praveenkumarreddy Y, Guruge KS, Subedi B. A review of the occurrence of pharmaceuticals and personal care products in Indian water bodies. Ecotoxicol Environ Saf. 2017 Mar;137:113-120. doi: 10.1016/j.ecoenv.2016.11.014. Epub 2016 Dec 19. PMID: 27915141. 16: Pires Dos Santos T, Damborg P, Moodley A, Guardabassi L. Systematic Review on Global Epidemiology of Methicillin-Resistant Staphylococcus pseudintermedius: Inference of Population Structure from Multilocus Sequence Typing Data. Front Microbiol. 2016 Oct 18;7:1599. doi: 10.3389/fmicb.2016.01599. PMID: 27803691; PMCID: PMC5067483. 17: O'Connor AM, Yuan C, Cullen JN, Coetzee JF, da Silva N, Wang C. A mixed treatment meta-analysis of antibiotic treatment options for bovine respiratory disease - An update. Prev Vet Med. 2016 Sep 15;132:130-139. doi: 10.1016/j.prevetmed.2016.07.003. Epub 2016 Aug 31. PMID: 27612392. 18: Piro B, Shi S, Reisberg S, Noël V, Anquetin G. Comparison of Electrochemical Immunosensors and Aptasensors for Detection of Small Organic Molecules in Environment, Food Safety, Clinical and Public Security. Biosensors (Basel). 2016 Feb 29;6(1):7. doi: 10.3390/bios6010007. PMID: 26938570; PMCID: PMC4810399. 19: Wideman RF Jr. Bacterial chondronecrosis with osteomyelitis and lameness in broilers: a review. Poult Sci. 2016 Feb;95(2):325-44. doi: 10.3382/ps/pev320. Epub 2015 Nov 2. PMID: 26527707. 20: Macedo N, Rovira A, Torremorell M. Haemophilus parasuis: infection, immunity and enrofloxacin. Vet Res. 2015 Oct 28;46:128. doi: 10.1186/s13567-015-0263-3. PMID: 26511717; PMCID: PMC4625873.

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