Synonym
AC-102; AC102; AC 102;
IUPAC/Chemical Name
6-fluoro-1-methyl-9H-pyrido[3,4-b]indole
InChi Key
SXFHVXCWQOKTFY-UHFFFAOYSA-N
InChi Code
1S/C12H9FN2/c1-7-12-9(4-5-14-7)10-6-8(13)2-3-11(10)15-12/h2-6,15H,1H3
SMILES Code
CC1=NC=CC2=C1NC3=CC=C(F)C=C23
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
200.22
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zhang Y, Hu X, Mu J, Hu Y, Zhou Y, Zhao H, Wu C, Pei R, Chen J, Chen X, Wang Y. Ac102 Participates in Nuclear Actin Polymerization by Modulating BV/ODV-C42 Ubiquitination during Autographa californica Multiple Nucleopolyhedrovirus Infection. J Virol. 2018 May 29;92(12):e00005-18. doi: 10.1128/JVI.00005-18. PMID: 29618641; PMCID: PMC5974488.
2: Hepp SE, Borgo GM, Ticau S, Ohkawa T, Welch MD. Baculovirus AC102 Is a Nucleocapsid Protein That Is Crucial for Nuclear Actin Polymerization and Nucleocapsid Morphogenesis. J Virol. 2018 May 14;92(11):e00111-18. doi: 10.1128/JVI.00111-18. PMID: 29540600; PMCID: PMC5952165.
3: Rommelspacher H, Bera S, Brommer B, Ward R, Kwiatkowska M, Zygmunt T, Theden F, Üsekes B, Eren N, Nieratschker M, Arnoldner C, Plontke SK, Hellmann-Regen J, Schlingensiepen R. A single dose of AC102 restores hearing in a guinea pig model of noise-induced hearing loss to almost prenoise levels. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2314763121. doi: 10.1073/pnas.2314763121. Epub 2024 Apr 1. PMID: 38557194; PMCID: PMC11009624.
4: Gandhi KM, Ohkawa T, Welch MD, Volkman LE. Nuclear localization of actin requires AC102 in Autographa californica multiple nucleopolyhedrovirus-infected cells. J Gen Virol. 2012 Aug;93(Pt 8):1795-1803. doi: 10.1099/vir.0.041848-0. Epub 2012 May 16. PMID: 22592260; PMCID: PMC3541763.
5: Hu X, Tian L, Li J, Zhou Y, Chen X, Mu J, Bai H, Zhang Y, Wang Y. Effects of CRM1-dependent nuclear export inhibition on viral structural protein nuclear accumulation during Autographa californica multiple nucleopolyhedrovirus infection. Virus Res. 2021 Oct 2;303:198504. doi: 10.1016/j.virusres.2021.198504. Epub 2021 Jul 13. PMID: 34271037.
6: Ohkawa T, Rowe AR, Volkman LE. Identification of six Autographa californica multicapsid nucleopolyhedrovirus early genes that mediate nuclear localization of G-actin. J Virol. 2002 Dec;76(23):12281-9. doi: 10.1128/jvi.76.23.12281-12289.2002. PMID: 12414968; PMCID: PMC136882.
7: Wang Q, Chen JZ, Wang Y, Wang XJ, Chen XW. [Localization of AcMNPV NLA genes in Sf9 cells]. Bing Du Xue Bao. 2012 Mar;28(2):172-7. Chinese. PMID: 22519180.
