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MedKoo Cat#: 556358 | Name: Navitoclax-piperazine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Navitoclax-piperazine, also known as ABT-263-piperazine, is a Navitoclax derative and is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine is a useful material to make PrOTAC agent DT2216.

Chemical Structure

Navitoclax-piperazine
Navitoclax-piperazine
CAS#2143096-93-7 (Navitoclax-piperazine)

Theoretical Analysis

MedKoo Cat#: 556358

Name: Navitoclax-piperazine

CAS#: 2143096-93-7 (Navitoclax-piperazine)

Chemical Formula: C47H56ClF3N6O5S3

Exact Mass: 972.3115

Molecular Weight: 973.63

Elemental Analysis: C, 57.98; H, 5.80; Cl, 3.64; F, 5.85; N, 8.63; O, 8.22; S, 9.88

Price and Availability

Size Price Availability Quantity
5mg USD 750.00 2 Weeks
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Related CAS #
2143096-93-7 (Navitoclax-piperazine) 923564-51-6 (free base) 1093851-28-5 (HCl)
Synonym
Navitoclax-piperazine; ABT-263-piperazine; Precursor for DT2216 (DT22 16, DT 2216);
IUPAC/Chemical Name
(R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((1-(phenylthio)-4-(piperazin-1-yl)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide
InChi Key
CRPNZDFOWRFBLZ-KXQOOQHDSA-N
InChi Code
InChI=1S/C47H56ClF3N6O5S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-56-26-28-57(29-27-56)39-14-10-35(11-15-39)45(58)54-65(61,62)41-16-17-43(44(30-41)64(59,60)47(49,50)51)53-38(19-23-55-24-21-52-22-25-55)33-63-40-6-4-3-5-7-40/h3-17,30,38,52-53H,18-29,31-33H2,1-2H3,(H,54,58)/t38-/m1/s1
SMILES Code
O=C(NS(=O)(C1=CC=C(N[C@@H](CSC2=CC=CC=C2)CCN3CCNCC3)C(S(=O)(C(F)(F)F)=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 973.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL