Synonym
Nicotinyl alcohol tartrate; NSC147492; NSC-147492; NSC 147492
IUPAC/Chemical Name
pyridin-3-ylmethanol (2R,3R)-2,3-dihydroxysuccinate
InChi Key
NPORIZAYKBQYLF-LREBCSMRSA-N
InChi Code
InChI=1S/C6H7NO.C4H6O6/c8-5-6-2-1-3-7-4-6;5-1(3(7)8)2(6)4(9)10/h1-4,8H,5H2;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
SMILES Code
OCc1cnccc1.O[C@@H](C(O)=O)[C@H](C(O)=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
to be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| To be determined |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
259.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: GILLHESPY RO. Nicotinyl alcohol tartrate in intermittent claudication. Br Med J. 1957 Jan 26;1(5012):207-8. doi: 10.1136/bmj.1.5012.207. PMID: 13383231; PMCID: PMC1974214.
2: Dujovne CA, Azarnoff DL, Pentikainen P, Manion CV, Hurwitz A. A comparative trial of clofibrate and nicotinyl alcohol tartrate in hyperlipoproteinemic patients. Am J Med Sci. 1979 May-Jun;277(3):255-61. doi: 10.1097/00000441-197905000-00002. PMID: 222145.
3: Winsor T. Thermography for studying nicotinyl alcohol tartrate. Angiology. 1975 Feb;26(2):225-32. doi: 10.1177/000331977502600206. PMID: 1090219.
4: NORWOOD WF. VASODILATOR EFFECTS OF NICOTINYL TARTRATE (RONIACOL TARTRATE). JAMA. 1963 Dec 14;186:1013. PMID: 14066712.
5: Alton C, Kowalski C, Mallon J, Marschhaus C. Observations on the cholesterol- lowering mechanism of nicotinic acid and nicotinyl alcohol tartrate. J Atheroscler Res. 1968 Mar-Apr;8(2):265-76. doi: 10.1016/s0368-1319(68)80062-6. PMID: 5664196.
6: BRANDMAN O, REDISCH W. Nicotinic alcohol tartrate (roniacol tartrate) in the treatment of peripheral vascular disease; report of 3 cases. J Med Soc N J. 1950 Jun;47(6):267-9. PMID: 15422301.
7: Badawy AA, Evans M. The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol. Biochem J. 1975 Jun;148(3):425-32. doi: 10.1042/bj1480425. PMID: 989; PMCID: PMC1165559.
8: Lange DE, Lübbert H, Omid A. Uber die Beeinflussung der gingivalen Entzündung durch Wirkstoffzusätze in Zahnpasten [Management of gingival inflammation with active ingredients in toothpaste]. Dtsch Zahnarztl Z. 1975 Jun;30(6):382-4. German. PMID: 1056849.
9: Kala H, Danz R, Bekemeier H, Moldenhauer H. In-vivo-Testung einer 3-Hydroxymethylpyridinhydrogentartrat-Matrixtablette. 2. Mitteilung: Vergleich der Wirkstoffliberation aus der Matrixform in vivo mit Radecol-Tabletten [In vivo testing of a 3-hydroxymethylpyridine hydrogen tartrate matrix tablet. Part 2: Comparison between the in vivo drug release from the matrix form and that from Radecol-tablets (author's transl)]. Pharmazie. 1980;35(4):216-21. German. PMID: 7403243.
10: PHILPOTT OS, WOODBURNE AR, PHILPOTT JA Jr. Roniacol tartrate in the treatment of dermatitis herpetiformis. J Invest Dermatol. 1952 Feb;18(2):87-8. doi: 10.1038/jid.1952.10. PMID: 14908182.
