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MedKoo Cat#: 125508 | Name: MK-8998 hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK-8998 is a T type calcium channel antagonist potentially for the treatment of schizophrenia. MK-8998 was not effective in treating acutely psychotic inpatients with schizophrenia, as measured by PANSS score at week 4.

Chemical Structure

MK-8998 hydrochloride
MK-8998 hydrochloride
CAS#2249709-38-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 125508

Name: MK-8998 hydrochloride

CAS#: 2249709-38-2 (HCl)

Chemical Formula: C20H24ClF3N2O2

Exact Mass: 416.1500

Molecular Weight: 416.87

Elemental Analysis: C, 57.62; H, 5.80; Cl, 8.50; F, 13.67; N, 6.72; O, 7.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
953778-58-0 (free base) 2249709-38-2 (HCl)
Synonym
JZP385 hydrochloride; Suvecaltamide hydrochloride; Suvecaltamide hydrochloride [USAN]; JZP-385 HYDROCHLORIDE; CX-8998 HYDROCHLORIDE; MK-8998 HYDROCHLORIDE; CHEMBL4802242
IUPAC/Chemical Name
(R)-2-(4-isopropylphenyl)-N-(1-(5-(2,2,2-trifluoroethoxy)pyridin-2-yl)ethyl)acetamide hydrochloride
InChi Key
KGFZANSMUKVDNC-PFEQFJNWSA-N
InChi Code
InChI=1S/C20H23F3N2O2.ClH/c1-13(2)16-6-4-15(5-7-16)10-19(26)25-14(3)18-9-8-17(11-24-18)27-12-20(21,22)23;/h4-9,11,13-14H,10,12H2,1-3H3,(H,25,26);1H/t14-;/m1./s1
SMILES Code
Cl.CC(C)C1=CC=C(CC(=O)N[C@H](C)C2=NC=C(OCC(F)(F)F)C=C2)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 416.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Egan MF, Zhao X, Smith A, Troyer MD, Uebele VN, Pidkorytov V, Cox K, Murphy M, Snavely D, Lines C, Michelson D. Randomized controlled study of the T-type calcium channel antagonist MK-8998 for the treatment of acute psychosis in patients with schizophrenia. Hum Psychopharmacol. 2013 Mar;28(2):124-33. doi: 10.1002/hup.2289. PubMed PMID: 23532746.