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MedKoo Cat#: 577315 | Name: Methophenazine diethanesulfonate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methophenazine diethanesulfonate is a Calmodulin antagonist.

Chemical Structure

Methophenazine diethanesulfonate
Methophenazine diethanesulfonate
CAS#1674-48-2

Theoretical Analysis

MedKoo Cat#: 577315

Name: Methophenazine diethanesulfonate

CAS#: 1674-48-2

Chemical Formula: C35H48ClN3O11S3

Exact Mass: 817.2139

Molecular Weight: 818.41

Elemental Analysis: C, 51.37; H, 5.91; Cl, 4.33; N, 5.13; O, 21.50; S, 11.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Metofenazate diesylate; Methophenazine diethanesulfonate
IUPAC/Chemical Name
Benzoic acid, 3,4,5-trimethoxy-, 2-(4-(3-(2-chlorophenothiazin-10-yl)propyl)-1-piperazinyl)ethyl ester, diethanesulfonate
InChi Key
YUUZEPKGGQPQLT-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H36ClN3O5S.2C2H6O3S/c1-37-26-19-22(20-27(38-2)30(26)39-3)31(36)40-18-17-34-15-13-33(14-16-34)11-6-12-35-24-7-4-5-8-28(24)41-29-10-9-23(32)21-25(29)35;2*1-2-6(3,4)5/h4-5,7-10,19-21H,6,11-18H2,1-3H3;2*2H2,1H3,(H,3,4,5)
SMILES Code
CCS(=O)(=O)O.CCS(=O)(=O)O.COc1cc(cc(OC)c1OC)C(=O)OCCN2CCN(CCCN3c4ccccc4Sc5ccc(Cl)cc35)CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Toxicity Data: Mouse - LD50, Intravenous (82mg/kg) - No effects reported Source: "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 30, 1972.

Preparing Stock Solutions

The following data is based on the product molecular weight 818.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Tkachuk VA, Baldenkov GN, Feoktistov IA, Men'shikov MY, Quast U, Herzig JW. Metofenazate as a more selective calmodulin inhibitor than trifluoperazine. Arzneimittelforschung. 1987 Sep;37(9):1013-7. PMID: 2449225. 2. Bergstrand H, Eriksson T, Hallberg A, Johansson B, Karabelas K, Michelsen P, Nybom A. Modulation of neutrophil superoxide generation by inhibitors of protein kinase C, calmodulin, diacylglycerol and myosin light chain kinases, and peptidyl prolyl cis-trans isomerase. J Pharmacol Exp Ther. 1992 Dec;263(3):1334-46. PMID: 1281879. 3. Bergstrand H, Lundquist B. Human basophil histamine release is differently affected by inhibitors of calmodulin, diacylglycerol kinase and peptidyl prolyl cis-trans isomerase in a secretagogue specific manner. Allergy. 1992 Aug;47(4 Pt 2):353-61. doi: 10.1111/j.1398-9995.1992.tb02071.x. PMID: 1280915.