MedKoo Cat#: 577317 | Name: Methopholine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methopholine hydrochloride is an opioid analgesic drug and isoquinoline derivative. Although it is not structurally related to most other opioids, Methopholine has around the analgesic activity as codeine and was evaluated for the treatment of postoperative pain. Metofoline tablets were marketed in the United States under the brand name of Versidyne, but the drug was withdrawn from the market in 1965 due to the occurrence of ophthalmic side-effects alongside the discovery that the drug could produce cataracts in dogs. NOT FOR INDIVIDUAL OR HUMAN USE.

Chemical Structure

Methopholine hydrochloride
Methopholine hydrochloride
CAS#7558-47-6

Theoretical Analysis

MedKoo Cat#: 577317

Name: Methopholine hydrochloride

CAS#: 7558-47-6

Chemical Formula: C20H25Cl2NO2

Exact Mass: 381.1262

Molecular Weight: 382.33

Elemental Analysis: C, 62.83; H, 6.59; Cl, 18.54; N, 3.66; O, 8.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Methopholine hydrochloride; Methopholine HCl
IUPAC/Chemical Name
Isoquinoline, 1-(2-(4-chlorophenyl)ethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, hydrochloride (1:1)
InChi Key
VKRFWQKEQQQVIZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H24ClNO2.ClH/c1-22-11-10-15-12-19(23-2)20(24-3)13-17(15)18(22)9-6-14-4-7-16(21)8-5-14;/h4-5,7-8,12-13,18H,6,9-11H2,1-3H3;1H
SMILES Code
Cl.COc1cc2CCN(C)C(CCc3ccc(Cl)cc3)c2cc1OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 382.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. CASS LJ, FREDERIK WS. METHOPHOLINE, A NEW ANALGESIC AGENT. Am J Med Sci. 1963 Nov;246:550-7. doi: 10.1097/00000441-196311000-00005. PMID: 14082642. 2. MOORE J, FOLDES FF, DAVIDSON GM. An evaluation of the efficacy of methopholine for the relief of postoperative pain. Am J Med Sci. 1962 Sep;244:337-43. doi: 10.1097/00000441-196209000-00010. PMID: 14475666.