Selatinib is a a potent dual EGFR/HER-2 inhibitor. Selatinib is also an analog of the quinazoline lapatinib with potential antineoplastic activity. Upon administration, selatinib reversibly blocks phosphorylation of both EGFR and ErbB2, thereby suppressing tumor growth in EGFR/ErbB-2-overexpressing tumor cells. The tyrosine kinases EGFR and ErbB2 have been implicated in the growth of various tumor types.
MedKoo Cat#: 125491
Name: Selatinib ditosilate
CAS#: 1452886-38-2 (ditosilate)
Chemical Formula: C43H42ClFN4O9S3
Exact Mass: 908.1800
Molecular Weight: 909.46
Elemental Analysis: C, 56.79; H, 4.66; Cl, 3.90; F, 2.09; N, 6.16; O, 15.83; S, 10.58
The following data is based on the product molecular weight 909.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
