Synonym
H 256; H-256; H256; Pro-thr-glu-phe-CH2NH-phe-arg-glu;
IUPAC/Chemical Name
((S)-2-((S)-4-carboxy-2-((2S,3R)-3-hydroxy-2-((S)-pyrrolidine-2-carboxamido)butanamido)butanamido)-3-phenylpropyl)-L-phenylalanyl-L-arginyl-L-glutamic acid
InChi Key
WNWJVPXOYQRRNI-MVPDBZEZSA-N
InChi Code
InChI=1S/C43H62N10O12/c1-25(54)36(53-37(59)29-14-8-20-46-29)41(63)51-31(16-18-34(55)56)38(60)49-28(22-26-10-4-2-5-11-26)24-48-33(23-27-12-6-3-7-13-27)40(62)50-30(15-9-21-47-43(44)45)39(61)52-32(42(64)65)17-19-35(57)58/h2-7,10-13,25,28-33,36,46,48,54H,8-9,14-24H2,1H3,(H,49,60)(H,50,62)(H,51,63)(H,52,61)(H,53,59)(H,55,56)(H,57,58)(H,64,65)(H4,44,45,47)/t25-,28+,29+,30+,31+,32+,33+,36+/m1/s1
SMILES Code
O=C(O)CC[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC1=CC=CC=C1)NC[C@@H](NC([C@H](CCC(O)=O)NC([C@H]([C@H](O)C)NC([C@H]2NCCC2)=O)=O)=O)CC3=CC=CC=C3)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
911.02
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Maha A, Rukachaisirikul V, Saithong S, Phongpaichit S, Poonsuwan W, Sakayaroj J, Saparpakorn P, Hannongbua S. Terezine derivatives from the fungus Phoma herbarum PSU-H256. Phytochemistry. 2016 Feb;122:223-229. doi: 10.1016/j.phytochem.2015.11.009. Epub 2015 Nov 27. PubMed PMID: 26626161.
2: Wang X, Xie L, Hu J, Jiang X, Xiang D, Gao J, Gao G. [Trimethoxystilbene and its effects on the proliferation and apoptosis of PASMCs]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Apr;37(4):390-9. doi: 10.3969/j.issn.1672-7347.2012.04.013. Chinese. PubMed PMID: 22561559.
3: Narasimha Murthy S, Hiremath SR. Clinical pharmacokinetic and pharmacodynamic evaluation of transdermal drug delivery systems of salbutamol sulfate. Int J Pharm. 2004 Dec 9;287(1-2):47-53. PubMed PMID: 15541911.
4: Adamopoulos D, Kapolla N, Nicopoulou S, Pappa A, Koukkou E, Gregoriou A. Assessment of Sertoli cell functional reserve and its relationship to sperm parameters. Int J Androl. 2003 Aug;26(4):215-25. PubMed PMID: 12846797.
5: Han X. Characterization and direct quantitation of ceramide molecular species from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry. Anal Biochem. 2002 Mar 15;302(2):199-212. PubMed PMID: 11878798.
6: Soares VA, Fan CD, Ward H. Mesangial overload in experimental membranous nephropathy. Braz J Med Biol Res. 1992;25(5):477-86. PubMed PMID: 1342223.
7: Cooper JB, Foundling SI, Hemmings A, Watson FE, Sibanda BL, Blundell TL, Jones DM, Hallett A, Atrash B, Szelke M. Inhibitors of aspartic proteinases and their relevance to the design of antihypertensive agents. Biochem Soc Trans. 1987 Aug;15(4):751-4. PubMed PMID: 3119394.
8: Foundling SI, Cooper J, Watson FE, Cleasby A, Pearl LH, Sibanda BL, Hemmings A, Wood SP, Blundell TL, Valler MJ, et al. High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes. Nature. 1987 May 28-Jun 3;327(6120):349-52. PubMed PMID: 3295561.
