FUN55031is a first-in-class, potent, selective, and bioavailable hCDC14A/B Inhibitor (inhibitor of human CDC14A and B phosphatases). FUN55031 was a compound reported by Jiajun Dong et al (J. Med. Chem. 2024, 67, 8817−8835). FUN55031 behaved as a reversible and competitive inhibitor for both hCDC14A and B with Ki values of 57.4 ± 7.6 and 90.0 ± 8.8 nM, respectively. FUN55031 was confirmed to be a genuine active-site-directed competitive inhibitor of both hCDC14A and hCDC14B. FUN55031 can engage its target and block CDC14-mediated p53 dephosphorylation in a cell-based assay with low μM efficacy. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 556371
Name: FUN55031
CAS#: 3048655-03-1
Chemical Formula:
Exact Mass: 0.0000
Molecular Weight: 0.00
Elemental Analysis:
The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
