RBN012811 | PROTAC targeting PARP14

MedKoo Cat#: 123556 | Name: RBN012811

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RBN012811 is a PROTAC targeting PARP14.

Chemical Structure

RBN012811

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 123556

Name: RBN012811

CAS#: N/A

Chemical Formula: C40H49FN8O6S

Exact Mass: 788.3500

Molecular Weight: 788.94

Elemental Analysis: C, 60.90; H, 6.26; F, 2.41; N, 14.20; O, 12.17; S, 4.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RBN012811; RBN-012811; RBN 012811

IUPAC/Chemical Name

2-(4-(((7-(cyclopentylamino)-5-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)thio)piperidin-1-yl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)acetamide

InChi Key

HTRNIXWEXIRUMI-UHFFFAOYSA-N

InChi Code

InChI=1S/C40H49FN8O6S/c41-28-20-25(44-24-8-3-4-9-24)21-30-36(28)38(53)46-32(45-30)23-56-26-14-18-48(19-15-26)22-34(51)43-17-6-2-1-5-16-42-29-11-7-10-27-35(29)40(55)49(39(27)54)31-12-13-33(50)47-37(31)52/h7,10-11,20-21,24,26,31,42,44H,1-6,8-9,12-19,22-23H2,(H,43,51)(H,45,46,53)(H,47,50,52)

SMILES Code

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCCCCCNC(CN4CCC(SCC(N5)=NC6=CC(NC7CCCC7)=CC(F)=C6C5=O)CC4)=O)=CC=C3)=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 788.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Poltronieri P, Miwa M, Masutani M. ADP-Ribosylation as Post-Translational Modification of Proteins: Use of Inhibitors in Cancer Control. Int J Mol Sci. 2021 Oct 7;22(19):10829. doi: 10.3390/ijms221910829. PMID: 34639169; PMCID: PMC8509805.