Synonym
K(D-1-Nal)-FwLLNH2, K-(D1Nal)-FwLL-NH2
IUPAC/Chemical Name
Lys-(D-1-Nal)-Phe-D-Trp-Leu-Leu-NH2
InChi Key
NCMQVOQOKBIHPA-MHRDGXECSA-N
InChi Code
InChI=1S/C51H67N9O6/c1-31(2)25-41(46(54)61)56-48(63)42(26-32(3)4)58-51(66)45(29-36-30-55-40-23-11-10-21-38(36)40)60-49(64)43(27-33-15-6-5-7-16-33)59-50(65)44(57-47(62)39(53)22-12-13-24-52)28-35-19-14-18-34-17-8-9-20-37(34)35/h5-11,14-21,23,30-32,39,41-45,55H,12-13,22,24-29,52-53H2,1-4H3,(H2,54,61)(H,56,63)(H,57,62)(H,58,66)(H,59,65)(H,60,64)/t39-,41-,42-,43-,44+,45+/m0/s1
SMILES Code
O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)[C@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](CC2=CC=CC3=C2C=CC=C3)NC([C@@H](N)CCCCN)=O)=O)=O)CC4=CNC5=CC=CC=C54
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
902.15
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Els S, Schild E, Petersen PS, Kilian TM, Mokrosinski J, Frimurer TM, Chollet C, Schwartz TW, Holst B, Beck-Sickinger AG. An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J Med Chem. 2012 Sep 13;55(17):7437-49. doi: 10.1021/jm300414b. Epub 2012 Sep 5. PMID: 22920150.
3: Fernandez G, Cabral A, Andreoli MF, Labarthe A, M'Kadmi C, Ramos JG, Marie J, Fehrentz JA, Epelbaum J, Tolle V, Perello M. Evidence Supporting a Role for Constitutive Ghrelin Receptor Signaling in Fasting-Induced Hyperphagia in Male Mice. Endocrinology. 2018 Feb 1;159(2):1021-1034. doi: 10.1210/en.2017-03101. PMID: 29300858.
4: Cornejo MP, Castrogiovanni D, Schiöth HB, Reynaldo M, Marie J, Fehrentz JA, Perello M. Growth hormone secretagogue receptor signalling affects high-fat intake independently of plasma levels of ghrelin and LEAP2, in a 4-day binge eating model. J Neuroendocrinol. 2019 Oct;31(10):e12785. doi: 10.1111/jne.12785. Epub 2019 Oct 2. PMID: 31469195.
