P-1946 | CAS#449806-40-0 | inhibitor

MedKoo Cat#: 584969 | Name: P-1946

Description:

WARNING: This product is for research use only, not for human or veterinary use.

P-1946 is an HIV-1 protease inhibitor.

Chemical Structure

P-1946

CAS#449806-40-0

Theoretical Analysis

MedKoo Cat#: 584969

Name: P-1946

CAS#: 449806-40-0

Chemical Formula: C29H41N5O6S

Exact Mass: 587.2778

Molecular Weight: 587.74

Elemental Analysis: C, 59.26; H, 7.03; N, 11.92; O, 16.33; S, 5.45

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

P-1946; P1946; P 1946

IUPAC/Chemical Name

Carbamic acid, ((1S)-2-(((5S)-5-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-6-hydroxyhexyl)amino)-1-(1H-indol-3-ylmethyl)-2-oxoethyl)-, methyl ester

InChi Key

KLFMLSLUVACAEA-HOFKKMOUSA-N

InChi Code

InChI=1S/C29H41N5O6S/c1-20(2)18-34(41(38,39)24-13-11-22(30)12-14-24)23(19-35)8-6-7-15-31-28(36)27(33-29(37)40-3)16-21-17-32-26-10-5-4-9-25(21)26/h4-5,9-14,17,20,23,27,32,35H,6-8,15-16,18-19,30H2,1-3H3,(H,31,36)(H,33,37)/t23-,27-/m0/s1

SMILES Code

O=C(OC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(NCCCC[C@H](N(S(=O)(C3=CC=C(N)C=C3)=O)CC(C)C)CO)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 587.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sévigny G, Stranix B, Tian B, Dubois A, Sauvé G, Petropoulos C, Lie Y, Hellmann N, Conway B, Yelle J. Antiviral activity and cross-resistance profile of P-1946, a novel human immunodeficiency virus type 1 protease inhibitor. Antiviral Res. 2006 Jun;70(2):17-20. Epub 2006 Jan 20. PubMed PMID: 16473417. 2: Corrections and clarifications. Science. 1993 Feb 5;259(5096):747. PubMed PMID: 17809322. 3: Benedetti S, Casamenti V, Benedetti M. Long-term endothelial changes in phakic eyes after Artisan intraocular lens implantation to correct myopia: five-year study. J Cataract Refract Surg. 2007 May;33(5):784-90. PubMed PMID: 17466848.