Scyliorhinin II | NK3 receptor peptide agonist

MedKoo Cat#: 128878 | Name: Scyliorhinin II (trifluoroacetate salt)

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Scyliorhinin II is a neurokinin-3 (NK3) receptor peptide agonist that has been found in dogfish intestines.

Chemical Structure

Scyliorhinin II (trifluoroacetate salt)

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128878

Name: Scyliorhinin II (trifluoroacetate salt)

CAS#: N/A

Chemical Formula: C79H120F3N21O28S3

Exact Mass: 1963.7726

Molecular Weight: 1965.12

Elemental Analysis: C, 48.29; H, 6.16; F, 2.90; N, 14.97; O, 22.80; S, 4.89

Price and Availability

Size	Price	Availability
1mg	USD 350.00	2 Weeks
5mg	USD 750.00	2 Weeks
10mg	USD 1,250.00	2 Weeks

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Related CAS #

No Data

Synonym

Scyliorhinin II (trifluoroacetate salt); SCYII; SCY2; Scyliorhinin 2

IUPAC/Chemical Name

2,2'-((6R,11R,14S,16aS,25S,27aS)-6-((S)-2-((S)-2-((S)-2-((S)-2-((S)-1-(L-seryl)pyrrolidine-2-carboxamido)-3-hydroxypropanamido)-4-amino-4-oxobutanamido)-3-hydroxypropanamido)-6-aminohexanamido)-11-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl)-5,13,16,21,24,27-hexaoxodocosahydro-1H,5H,10H-dipyrrolo[2,1-j:2',1'-s][1,2]dithia[5,8,11,14,17,20]hexaazacyclotricosine-14,25-diyl)diacetic acid--2,2,2-trifluoroacetic acid (1/1)

InChi Key

VQTIVRODJVVFQG-JKVSPIOXSA-N

InChi Code

InChI=1S/C77H119N21O26S3.C2HF3O2/c1-38(2)26-44(65(112)85-42(62(81)109)20-25-125-5)84-57(103)31-82-75(122)61(39(3)4)95-68(115)45(27-40-14-7-6-8-15-40)87-71(118)51-36-126-127-37-52(77(124)98-24-13-19-55(98)73(120)89-47(29-59(105)106)63(110)83-32-58(104)96-22-11-17-53(96)72(119)90-48(30-60(107)108)67(114)93-51)94-64(111)43(16-9-10-21-78)86-69(116)49(34-100)91-66(113)46(28-56(80)102)88-70(117)50(35-101)92-74(121)54-18-12-23-97(54)76(123)41(79)33-99;3-2(4,5)1(6)7/h6-8,14-15,38-39,41-55,61,99-101H,9-13,16-37,78-79H2,1-5H3,(H2,80,102)(H2,81,109)(H,82,122)(H,83,110)(H,84,103)(H,85,112)(H,86,116)(H,87,118)(H,88,117)(H,89,120)(H,90,119)(H,91,113)(H,92,121)(H,93,114)(H,94,111)(H,95,115)(H,105,106)(H,107,108);(H,6,7)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,61-;/m0./s1

SMILES Code

O=C([C@H](CSSC[C@H](NC([C@@H](N1)CC(O)=O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)=O)CC2=CC=CC=C2)=O)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CCC3)N3C([C@@H](N)CO)=O)=O)=O)=O)=O)=O)N4[C@@](C(N[C@H](C(NCC(N(CCC5)[C@]5([H])C1=O)=O)=O)CC(O)=O)=O)([H])CCC4.OC(C(F)(F)F)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,965.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Buck, S.H., and Krstenansky, J.L. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur. J. Pharmacol. 144(1), 109-111 (1987). 2. Kitazawa, T. Excitatory responses to scyliorhinins I and II in smooth muscle strips isolated from the carp intestinal bulb (Cyprinus carpio). Naunyn Schmiedebergs Arch Pharmacol. 343(5), 525-531 (1991). 3. Raffa, R.B., Martinez, R.P., and Connelly, C.D. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: Differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci. Lett. 158(1), 87-91 (1993).