Trodusquemine, also known as MSI-1436 and MSI-1436C, is a protein tyrosine phosphatase PTP-1B inhibitor potentially for the treatment of type 2 diabetes. Trodusquemine significantly enhanced insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and STAT3, direct targets of PTP1B, in HepG2 cells in vitro and/or hypothalamic tissue in vivo.
MedKoo Cat#: 125457
Name: Trodusquemine lactate
CAS#: 1309370-86-2 (lactate)
Chemical Formula: C46H90N4O14S
Exact Mass: 0.0000
Molecular Weight: 955.30
Elemental Analysis: C, 57.84; H, 9.50; N, 5.86; O, 23.45; S, 3.36
The following data is based on the product molecular weight 955.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
