TG100801 or TG-100801 is a dual inhibitor of both VEGFr2 and the Src family (Src and YES) kinases as a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration. TG100801 is a multi-kinases inhibitor. It is a pro-drug version of TG100572. Age-related macular degeneration (AMD) is the leading cause of blindness in the Western world for those patients aged 50 years or older.
MedKoo Cat#: 125609
Name: TG 100801 Hydrochloride
CAS#: 1018069-81-2 (HCl)
Chemical Formula: C33H31Cl2N5O3
Exact Mass: 615.1800
Molecular Weight: 616.54
Elemental Analysis: C, 64.29; H, 5.07; Cl, 11.50; N, 11.36; O, 7.78
The following data is based on the product molecular weight 616.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
