MedKoo Cat#: 125419 | Name: Dimesna free acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimesna is a prodrug of mesna (dimer of mesna). Dimesna is reduced to mesna in the kidneys. Dimesna does not prevent cellular damage by metabolites of ifosfamide and cyclophosphamide in the renal tubular cell line LLC-PK1.

Chemical Structure

Dimesna free acid
CAS#45127-11-5 (free acid)

Theoretical Analysis

MedKoo Cat#: 125419

Name: Dimesna free acid

CAS#: 45127-11-5 (free acid)

Chemical Formula: C4H10O6S4

Exact Mass: 281.9400

Molecular Weight: 282.36

Elemental Analysis: C, 17.02; H, 3.57; O, 34.00; S, 45.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
45127-11-5; 2,2'-Dithiodiethanesulfonic acid; 2,2'-disulfanediyldiethanesulfonic acid; 2-(2-sulfoethyldisulfanyl)ethanesulfonic acid
IUPAC/Chemical Name
2,2'-disulfanediylbis(ethane-1-sulfonic acid)
InChi Key
BYUKOOOZTSTOOH-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H10O6S4/c5-13(6,7)3-1-11-12-2-4-14(8,9)10/h1-4H2,(H,5,6,7)(H,8,9,10)
SMILES Code
OS(=O)(=O)CCSSCCS(O)(=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 282.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Reddy V, Winston NR. Mesna. 2023 Jun 12. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32310481. 2: Cutler MJ, Velenosi TJ, Bodalia A, House AA, Urquhart BL, Freeman DJ. Enzymatic and non-enzymatic mechanisms of dimesna metabolism. Amino Acids. 2015 Mar;47(3):511-23. doi: 10.1007/s00726-014-1882-0. Epub 2014 Dec 10. PMID: 25488427. 3: Goren MP, Hsu LC, Li JT. Reduction of dimesna to mesna by the isolated perfused rat liver. Cancer Res. 1998 Oct 1;58(19):4358-62. PMID: 9766664. 4: el-Yazigi A, Ernst P, al-Rawithi S, Legayada E, Raines DA. Pharmacokinetics of mesna and dimesna after simultaneous intravenous bolus and infusion administration in patients undergoing bone marrow transplantation. J Clin Pharmacol. 1997 Jul;37(7):618-24. doi: 10.1002/j.1552-4604.1997.tb04344.x. PMID: 9243355. 5: Cutler MJ, Urquhart BL, Velenosi TJ, Meyer Zu Schwabedissen HE, Dresser GK, Leake BF, Tirona RG, Kim RB, Freeman DJ. In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol. 2012 Apr;52(4):530-42. doi: 10.1177/0091270011400414. Epub 2011 Apr 19. PMID: 21505084.