MedKoo Cat#: 125238 | Name: GUN69397
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GUN69397, also named as di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), is a novel thiosemicarbazone, inhibits neuroblastoma growth in vitro and vivo via multiple mechanisms.

Chemical Structure

GUN69397
GUN69397
CAS#1382469-39-7 (free base)

Theoretical Analysis

MedKoo Cat#: 125238

Name: GUN69397

CAS#: 1382469-39-7 (free base)

Chemical Formula: C19H23N5S

Exact Mass: 353.1700

Molecular Weight: 353.49

Elemental Analysis: C, 64.56; H, 6.56; N, 19.81; S, 9.07

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
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Synonym
DP4cych4mt; Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone; DPC; GUN69397; GUN 69397; GUN-69397
IUPAC/Chemical Name
N-cyclohexyl-2-(di(pyridin-2-yl)methylene)-N-methylhydrazine-1-carbothioamide
InChi Key
GNLZNQJBZNOUBM-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23N5S/c1-24(15-9-3-2-4-10-15)19(25)23-22-18(16-11-5-7-13-20-16)17-12-6-8-14-21-17/h5-8,11-15H,2-4,9-10H2,1H3,(H,23,25)
SMILES Code
CN(C1CCCCC1)C(=S)NN=C(C2=CC=CC=N2)C3=CC=CC=N3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 353.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Paukovcekova S, Skoda J, Neradil J, Mikulenkova E, Chlapek P, Sterba J, Richardson DR, Veselska R. Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms. Cancers (Basel). 2020 Dec 15;12(12):3781. doi: 10.3390/cancers12123781. PMID: 33334021; PMCID: PMC7765366. 2: Guo ZL, Richardson DR, Kalinowski DS, Kovacevic Z, Tan-Un KC, Chan GC. The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms. J Hematol Oncol. 2016 Sep 27;9(1):98. doi: 10.1186/s13045-016-0330-x. PMID: 27678372; PMCID: PMC5039880.