IUPAC/Chemical Name
(3,8'-Bi-4H-1-benzopyran)-4,4'-dione, 2,2',3,3'-tetrahydro-3',5,5',7,7'-pentahydroxy-2'-(3-hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)-, (2S,2'R,3R,3'R)-
InChi Key
GJWXCPDVDRIBKP-CNTBMXMRSA-N
InChi Code
InChI=1S/C31H24O12/c1-41-20-7-4-13(8-16(20)34)30-28(40)27(39)24-19(37)11-18(36)23(31(24)43-30)25-26(38)22-17(35)9-15(33)10-21(22)42-29(25)12-2-5-14(32)6-3-12/h2-11,25,28-30,32-37,40H,1H3/t25-,28-,29+,30+/m0/s1
SMILES Code
O=C1[C@H](C2=C3C(C([C@H](O)[C@@H](C4=CC=C(OC)C(O)=C4)O3)=O)=C(O)C=C2O)[C@@H](C5=CC=C(O)C=C5)OC6=CC(O)=CC(O)=C16
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
588.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Iwu MM. Antihepatoxic constituents of Garcinia kola seeds. Experientia. 1985 May 15;41(5):699-700. PubMed PMID: 3838940.
2: Tshibangu PT, Kapepula PM, Kapinga MJK, Lupona HK, Ngombe NK, Kalenda DT, Jansen O, Wauters JN, Tits M, Angenot L, Rozet E, Hubert P, Marini RD, Frédérich M. Fingerprinting and validation of a LC-DAD method for the analysis of biflavanones in Garcinia kola-based antimalarial improved traditional medicines. J Pharm Biomed Anal. 2016 Sep 5;128:382-390. doi: 10.1016/j.jpba.2016.04.042. Epub 2016 Jun 9. PubMed PMID: 27343901.
3: Okunji CO, Ware TA, Hicks RP, Iwu MM, Skanchy DJ. Capillary electrophoresis determination of biflavanones from Garcinia kola in three traditional African medicinal formulations. Planta Med. 2002 May;68(5):440-4. PubMed PMID: 12058322.
4: Kolawole AN, Akinladejo VT, Elekofehinti OO, Akinmoladun AC, Kolawole AO. Experimental and computational modeling of interaction of kolaviron-kolaflavanone with aldehyde dehydrogenase. Bioorg Chem. 2018 Aug;78:68-79. doi: 10.1016/j.bioorg.2018.02.012. Epub 2018 Feb 27. PubMed PMID: 29533216.
5: Farombi EO, Tahnteng JG, Agboola AO, Nwankwo JO, Emerole GO. Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract. Food Chem Toxicol. 2000 Jun;38(6):535-41. PubMed PMID: 10828505.
6: Adaramoye OA, Nwaneri VO, Anyanwu KC, Farombi EO, Emerole GO. Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats. Clin Exp Pharmacol Physiol. 2005 Jan-Feb;32(1-2):40-6. PubMed PMID: 15730433.
