Synonym
IDO-IN-2; IDO IN-2; IDOIN-2; IDO-IN2; IDO IN 2; IDOIN-2; PCC0208009
IUPAC/Chemical Name
Urea, N-[4-[bis(2-methylpropyl)amino]-2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-N'-(4-methylphenyl)-
InChi Key
CJNMMPAEIYFQIJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C29H35N7O/c1-19(2)17-36(18-20(3)4)27-15-12-22(24-8-6-7-9-25(24)28-32-34-35-33-28)16-26(27)31-29(37)30-23-13-10-21(5)11-14-23/h6-16,19-20H,17-18H2,1-5H3,(H2,30,31,37)(H,32,33,34,35)
SMILES Code
O=C(NC1=CC=C(C)C=C1)NC2=CC(C3=CC=CC=C3C4=NNN=N4)=CC=C2N(CC(C)C)CC(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
497.65
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wang Y, Li CM, Han R, Wang ZZ, Gao YL, Zhu XY, Yu X, Du GY, Wang HB, Tian JW,
Fu FH. PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and
co-morbidities by regulating synaptic plasticity of ACC and amygdala. Biochem
Pharmacol. 2020 Jul;177:113926. doi: 10.1016/j.bcp.2020.113926. Epub 2020 Mar
23. PMID: 32217098.
2: Sun S, Du G, Xue J, Ma J, Ge M, Wang H, Tian J. PCC0208009 enhances the anti-
tumor effects of temozolomide through direct inhibition and transcriptional
regulation of indoleamine 2,3-dioxygenase in glioma models. Int J Immunopathol
Pharmacol. 2018 Jan-Dec;32:2058738418787991. doi: 10.1177/2058738418787991.
PMID: 29993291; PMCID: PMC6047256.
3: Jiang X, Li X, Zheng S, Du G, Ma J, Zhang L, Wang H, Tian J. Comparison study
of different indoleamine-2,3 dioxygenase inhibitors from the perspective of
pharmacodynamic effects. Int J Immunopathol Pharmacol. 2020 Jan-
Dec;34:2058738420950584. doi: 10.1177/2058738420950584. PMID: 32962460; PMCID:
PMC7517983.
