BAOP-16 is a near-infrared fluorescent (NIRF) probe. BAOP-16 targets diverse soluble Aβ aggregates. BAOP-16, whose molecular shape resembles “y”, showed a marked selective increase in fluorescence intensity upon binding to soluble Aβ aggregates in the near-infrared region and a high binding affinity for them. Additionally, BAOP-16 could detect Aβ oligomers in the brains of Aβ-inoculated model mice. In an in vivo fluorescence imaging study of BAOP-16, brains of AD model mice displayed significantly higher fluorescence signals than those of wild-type mice. These results indicate that BAOP-16 could be useful for the in vivo NIRF imaging of diverse soluble Aβ aggregates.
MedKoo Cat#: 125210
Name: BAOP-16
CAS#: N/A
Chemical Formula: C33H30BF2N3O
Exact Mass: 533.2400
Molecular Weight: 533.43
Elemental Analysis: C, 74.30; H, 5.67; B, 2.03; F, 7.12; N, 7.88; O, 3.00
The following data is based on the product molecular weight 533.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
