WB214 is a MDM2 degrader (IC50 = 1.2 nM). WB214 was identified as the most potent anti-proliferative agent in various leukemia cell lines. WB214 not only effectively induced the degradation of MDM2, but also led to the degradation of p53. Further studies revealed that WB214 degraded MDM2 as a molecular glue. Finally, it was found that WB214 could potently degrade GSPT1, which could rationalize the inhibition of cell growth.
MedKoo Cat#: 121013
Name: WB214
CAS#: 2640723-72-2
Chemical Formula: C44H43ClF3N5O7
Exact Mass: 845.2803
Molecular Weight: 846.30
Elemental Analysis: C, 62.45; H, 5.12; Cl, 4.19; F, 6.73; N, 8.28; O, 13.23
The following data is based on the product molecular weight 846.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
