U69593 | CAS#6744-75-1 | κ1-opioid Receptor Agonist

MedKoo Cat#: 532850 | Name: U69593 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

U69593 is a a selective KOR-1 (κ1-opioid receptor) agonist. U-69593 is known to inhibit cocaine sensitization in meso-limbic dopamine neurons by normalizing basal overflow of dopamine.

Chemical Structure

U69593 HCl

CAS#U69593 HCl

Theoretical Analysis

MedKoo Cat#: 532850

Name: U69593 HCl

CAS#: U69593 HCl

Chemical Formula: C22H33ClN2O2

Exact Mass:

Molecular Weight: 392.97

Elemental Analysis: C, 67.24; H, 8.46; Cl, 9.02; N, 7.13; O, 8.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

1313288-99-1 (free base) 96744-75-1 (free base) U69593 HCl U-69593 Maleate

Synonym

U69593, U 69593, U-69593; U69593 HCl; U69593 hydrochloride.

IUPAC/Chemical Name

N-methyl-2-phenyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide hydrochloride

InChi Key

WUTZCCGGQOITTM-JLBKCEDKSA-N

InChi Code

InChI=1S/C22H32N2O2.ClH/c1-23(21(25)16-18-8-3-2-4-9-18)19-10-12-22(11-7-15-26-22)17-20(19)24-13-5-6-14-24;/h2-4,8-9,19-20H,5-7,10-17H2,1H3;1H/t19-,20-,22-;/m0./s1

SMILES Code

O=C(N(C)[C@@H](CC1)[C@@H](N2CCCC2)C[C@@]31CCCO3)CC4=CC=CC=C4.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 392.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Escobar Adel P, Cornejo FA, Andrés ME, Fuentealba JA. Repeated treatment with the kappa opioid receptor agonist U69593 reverses enhanced K+ induced dopamine release in the nucleus accumbens, but not the expression of locomotor sensitization in amphetamine-sensitized rats. Neurochem Int. 2012 Mar;60(4):344-9. doi: 10.1016/j.neuint.2012.01.014. Epub 2012 Jan 28. PubMed PMID: 22306346. 2: Morani AS, Kivell B, Prisinzano TE, Schenk S. Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats. Pharmacol Biochem Behav. 2009 Dec;94(2):244-9. doi: 10.1016/j.pbb.2009.09.002. Epub 2009 Sep 10. PubMed PMID: 19747933; PubMed Central PMCID: PMC3021564. 3: Perreault ML, Graham D, Scattolon S, Wang Y, Szechtman H, Foster JA. Cotreatment with the kappa opioid agonist U69593 enhances locomotor sensitization to the D2/D3 dopamine agonist quinpirole and alters dopamine D2 receptor and prodynorphin mRNA expression in rats. Psychopharmacology (Berl). 2007 Nov;194(4):485-96. Epub 2007 Jul 10. PubMed PMID: 17619861.