Synonym
S 15931; S15931; S-15931
IUPAC/Chemical Name
Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2-(2,3-dihydro-1H-inden-1-yl)ethyl)-
InChi Key
OARKPUCUFAIZCW-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H28N2O2/c1-2-5-20-18(4-1)8-9-19(20)10-11-24-12-14-25(15-13-24)21-6-3-7-22-23(21)27-17-16-26-22/h1-7,19H,8-17H2
SMILES Code
N1(C2=C3OCCOC3=CC=C2)CCN(CCC4CCC5=C4C=CC=C5)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
364.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Millan MJ, Seguin L, Honoré P, Girardon S, Bervoets K. Pro- and antinociceptive actions of serotonin (5-HT)1A agonists and antagonists in rodents: relationship to algesiometric paradigm. Behav Brain Res. 1996;73(1-2):69-77. PubMed PMID: 8788480.
2: Schreiber R, Brocco M, Lefèbvre de Ladonchamps B, Monneyron S, Millan MJ. A drug discrimination analysis of the actions of novel serotonin1A receptor ligands in the rat using the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin. J Pharmacol Exp Ther. 1995 Nov;275(2):822-31. PubMed PMID: 7473172.
3: Gobert A, Lejeune F, Rivet JM, Audinot V, Newman-Tancredi A, Millan MJ. Modulation of the activity of central serotoninergic neurons by novel serotonin1A receptor agonists and antagonists: a comparison to adrenergic and dopaminergic neurons in rats. J Pharmacol Exp Ther. 1995 Jun;273(3):1032-46. PubMed PMID: 7791073.
4: Millan MJ, Canton H, Gobert A, Lejeune F, Rivet JM, Bervoets K, Brocco M, Widdowson P, Mennini T, Audinot V, et al. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther. 1994 Jan;268(1):337-52. PubMed PMID: 8301575.
