JXL001 | CAS#unknown | MPC inhibitor

MedKoo Cat#: 463965 | Name: JXL001

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JXL001, also known as UK-5099, is a mitochondrial pyruvate carrier (MPC ) inhibitor for potential treatment of hair loss.

Chemical Structure

JXL001

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 463965

Name: JXL001

CAS#: unknown

Chemical Formula: C18H12N2O2

Exact Mass: 288.0899

Molecular Weight: 288.31

Elemental Analysis: C, 74.99; H, 4.20; N, 9.72; O, 11.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JXL001; JXL 001; JXL-001;

IUPAC/Chemical Name

(E)-2-cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid

InChi Key

BIZNHCWFGNKBBZ-JLHYYAGUSA-N

InChi Code

InChI=1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+

SMILES Code

N#C/C(C(O)=O)=C\C1=CN(C2=CC=CC=C2)C3=CC=CC=C31

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 288.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Liu X, Flores AA, Situ L, Gu W, Ding H, Christofk HR, Lowry WE, Jung ME. Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss. J Med Chem. 2021 Feb 3. doi: 10.1021/acs.jmedchem.0c01570. Epub ahead of print. PMID: 33534563.