MedKoo Cat#: 125147 | Name: SI-2 Hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SI-2 hydrochloride (EPH 116 hydrochloride) is an inhibitor of Steroid receptor coactivator 3 (SRC-3).

Chemical Structure

SI-2 Hydrochloride
SI-2 Hydrochloride
CAS#1992052-49-9

Theoretical Analysis

MedKoo Cat#: 125147

Name: SI-2 Hydrochloride

CAS#: 1992052-49-9

Chemical Formula: C15H16ClN5

Exact Mass: 301.1100

Molecular Weight: 301.78

Elemental Analysis: C, 59.70; H, 5.34; Cl, 11.75; N, 23.21

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
25mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
SI-2 hydrochloride; 1-methyl-N-[(Z)-1-pyridin-2-ylethylideneamino]benzimidazol-2-amine;hydrochloride; 1992052-49-9; 1-(2-Pyridinyl)ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone hydrochloride
IUPAC/Chemical Name
1-methyl-N-[(Z)-1-pyridin-2-ylethylideneamino]benzimidazol-2-amine;hydrochloride
InChi Key
CDYJHORKRVKALB-VVTVMFAVSA-N
InChi Code
InChI=1S/C15H15N5.ClH/c1-11(12-7-5-6-10-16-12)18-19-15-17-13-8-3-4-9-14(13)20(15)2;/h3-10H,1-2H3,(H,17,19);1H/b18-11-;
SMILES Code
C/C(C1=NC=CC=C1)=N/NC2=NC3=CC=CC=C3N2C.[H]Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 301.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Liu L, Xu X, Zhang N, Zhang Y, Zhao K. Acetylase inhibitor SI-2 is a potent anti-inflammatory agent by inhibiting NLRP3 inflammasome activation. Int Immunopharmacol. 2020 Oct;87:106829. doi: 10.1016/j.intimp.2020.106829. Epub 2020 Jul 28. PMID: 32736194.