SIAIS164018 is a Brigatinib Degrader with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile. SIAIS164018 could degrade not only ALK fusion proteins in activating or G1202R-mutated form but also mutant EGFR with L858R + T790M, which are two most important targets in non-small-cell lung cancer. SIAIS164018 strongly inhibited cell migration and invasion of Calu-1 and MDA-MB-231. SIAIS164018 degrades several important oncoproteins involved in metastasis such as FAK, PYK2, and PTK6.
MedKoo Cat#: 464853
Name: SIAIS164018
CAS#: 2353492-68-7
Chemical Formula: C43H48ClN10O7P
Exact Mass: 882.3134
Molecular Weight: 883.34
Elemental Analysis: C, 58.47; H, 5.48; Cl, 4.01; N, 15.86; O, 12.68; P, 3.51
The following data is based on the product molecular weight 883.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
