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MedKoo Cat#: 561489 | Name: SI-2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SI-2, also known as EPH-116, is a small-molecule inhibitor (SMI) of steroid receptor coactivator-3 (SRC-3 or AIB1). SI-2 can selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct physical interactions with SRC-3, and selectively induce breast cancer cell death with IC50 values in the low nanomolar range (3-20 nM), but not affect normal cell viability.

Chemical Structure

SI-2
SI-2
CAS#223788-33-8

Theoretical Analysis

MedKoo Cat#: 561489

Name: SI-2

CAS#: 223788-33-8

Chemical Formula: C15H15N5

Exact Mass: 265.1327

Molecular Weight: 265.32

Elemental Analysis: C, 67.90; H, 5.70; N, 26.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SI-2; SI 2; SI2; EPH-116; EPH 116; EPH116;
IUPAC/Chemical Name
1-(2-Pyridinyl)-ethanone 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone
InChi Key
JNNXERNBPXXNLK-WOJGMQOQSA-N
InChi Code
InChI=1S/C15H15N5/c1-11(12-7-5-6-10-16-12)18-19-15-17-13-8-3-4-9-14(13)20(15)2/h3-10H,1-2H3,(H,17,19)/b18-11+
SMILES Code
C/C(C1=NC=CC=C1)=N\NC2=NC3=CC=CC=C3N2C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 265.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Rohira AD, Yan F, Wang L, Wang J, Zhou S, Lu A, Yu Y, Xu J, Lonard DM, O'Malley BW. Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res. 2017 Aug 15;77(16):4293-4304. doi: 10.1158/0008-5472.CAN-16-2982. Epub 2017 Jun 13. PubMed PMID: 28611048; PubMed Central PMCID: PMC5559321. 2: Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang J. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5. doi: 10.1073/pnas.1604274113. Epub 2016 Apr 15. PubMed PMID: 27084884; PubMed Central PMCID: PMC4983835.