SHR2415 is a Novel Pyrrole-Fused Urea Scaffold ERK1/2 Inhibitor with IC50 = 2.8 nM. SHR2415 was shown to be a highly potent ERK1/2 inhibitor that exhibited high cell potency based on the Colo205 assay. In addition, SHR2415 displayed favorable PK profiles across species as well as robust in vivo efficacy in a mouse Colo205 xenograft model.
MedKoo Cat#: 466104
Name: SHR2415
CAS#: unknown
Chemical Formula: C23H22ClN7O2
Exact Mass: 463.1524
Molecular Weight: 463.93
Elemental Analysis: C, 59.55; H, 4.78; Cl, 7.64; N, 21.13; O, 6.90
The following data is based on the product molecular weight 463.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
