MedKoo Cat#: 125049 | Name: MSNBA
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MSNBA is a specific inhibitor of GLUT5 fructose transport in proteoliposomes.

Chemical Structure

MSNBA
MSNBA
CAS#852702-51-3

Theoretical Analysis

MedKoo Cat#: 125049

Name: MSNBA

CAS#: 852702-51-3

Chemical Formula: C14H12N2O6S

Exact Mass: 336.0416

Molecular Weight: 336.32

Elemental Analysis: C, 50.00; H, 3.60; N, 8.33; O, 28.54; S, 9.53

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 4 Weeks
100mg USD 750.00 4 Weeks
200mg USD 1,250.00 4 Weeks
500mg USD 2,650.00 4 Weeks
1g USD 3,650.00 4 Weeks
2g USD 5,950.00 4 Weeks
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Related CAS #
No Data
Synonym
MSNBA; MS-NBA; MSN-BA
IUPAC/Chemical Name
N-(4-(methylsulfonyl)-2-nitrophenyl)benzo[d][1,3]dioxol-5-amine
InChi Key
FUVYUOPHDIDJOP-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H12N2O6S/c1-23(19,20)10-3-4-11(12(7-10)16(17)18)15-9-2-5-13-14(6-9)22-8-21-13/h2-7,15H,8H2,1H3
SMILES Code
O=[N+](C1=CC(S(=O)(C)=O)=CC=C1NC2=CC3=C(OCO3)C=C2)[O-]
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 336.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: George Thompson AM, Ursu O, Babkin P, Iancu CV, Whang A, Oprea TI, Choe JY. Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation. Sci Rep. 2016 Apr 14;6:24240. doi: 10.1038/srep24240. PMID: 27074918; PMCID: PMC4831007. 2: Tripp J, Essl C, Iancu CV, Boles E, Choe JY, Oreb M. Establishing a yeast- based screening system for discovery of human GLUT5 inhibitors and activators. Sci Rep. 2017 Jul 24;7(1):6197. doi: 10.1038/s41598-017-06262-4. PMID: 28740135; PMCID: PMC5524692. 3: Włodarczyk J, Włodarczyk M, Zielińska M, Jędrzejczak B, Dziki Ł, Fichna J. Blockade of fructose transporter protein GLUT5 inhibits proliferation of colon cancer cells: proof of concept for a new class of anti-tumor therapeutics. Pharmacol Rep. 2021 Jun;73(3):939-945. doi: 10.1007/s43440-021-00281-9. Epub 2021 May 29. PMID: 34052986; PMCID: PMC8180478. 4: Hwang JY, Attia RR, Carrillo AK, Connelly MC, Guy RK. Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1891-5. doi: 10.1016/j.bmcl.2012.12.055. Epub 2013 Jan 8. PMID: 23414840; PMCID: PMC3594046.