Carbobenzoxyproline | CAS#1148-11-4 | inhibitor of prolidase

MedKoo Cat#: 596468 | Name: Carbobenzoxyproline

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carbobenzoxyproline is an inhibitor of prolidase.

Chemical Structure

Carbobenzoxyproline

CAS#1148-11-4

Theoretical Analysis

MedKoo Cat#: 596468

Name: Carbobenzoxyproline

CAS#: 1148-11-4

Chemical Formula: C13H15NO4

Exact Mass: 249.1001

Molecular Weight: 249.26

Elemental Analysis: C, 62.64; H, 6.07; N, 5.62; O, 25.67

Price and Availability

Size	Price	Availability	Quantity
10g	USD 250.00	2 Weeks
25g	USD 450.00	2 Weeks

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Related CAS #

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Synonym

Carbobenzoxyproline; Benzyloxycarbonylproline; N-Benzyloxycarbonylproline; Carbobenzoxy-S-proline; Z-Pro-OH; N-Cbz-L-proline; Z-L-Proline

IUPAC/Chemical Name

((benzyloxy)carbonyl)-L-proline

InChi Key

JXGVXCZADZNAMJ-NSHDSACASA-N

InChi Code

InChI=1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1

SMILES Code

O=C(N1[C@H](C(O)=O)CCC1)OCC2=CC=CC=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 249.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Surazynski A, Miltyk W, Prokop I, Palka J. Prolidase-dependent regulation of TGF β (corrected) and TGF β receptor expressions in human skin fibroblasts. Eur J Pharmacol. 2010 Dec 15;649(1-3):115-9. doi: 10.1016/j.ejphar.2010.09.034. Epub 2010 Sep 21. PubMed PMID: 20868675. 2: Mittal S, Song X, Vig BS, Amidon GL. Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma. Pharm Res. 2007 Jul;24(7):1290-8. Epub 2007 Mar 22. PubMed PMID: 17377743. 3: Lupi A, Rossi A, Vaghi P, Gallanti A, Cetta G, Forlino A. N-benzyloxycarbonyl-L-proline: an in vitro and in vivo inhibitor of prolidase. Biochim Biophys Acta. 2005 Jun 30;1744(2):157-63. Epub 2005 Apr 9. PubMed PMID: 15878628. 4: Dolenga M, Hechtman P. Cytotoxicity of carbobenzoxy-protected amino acids. In Vitro Cell Dev Biol. 1992 May;28A(5):300-2. PubMed PMID: 1597402.