Boronophenylalanine B-10 (also known as BPA) is a radiation sensitizer that contains 10B, a stable isotope of boron. Borofalan (10B) is a boronated phenylalanine and boron (boron-10) carrier that may be used in boron neutron capture therapy (BNCT), with potential antineoplastic activity. Upon administration, borofalan (10B) is absorbed mostly by tumor cells. When exposed to neutron irradiation, borofalan (10B) absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radiotargeting of tumor cells spares adjacent normal tissues.
MedKoo Cat#: 124629
Name: Borofalan B10
CAS#: 80994-59-8 (B10 labeled)
Chemical Formula: C9H1210BNO4
Exact Mass: 208.0900
Molecular Weight: 208.21
Elemental Analysis: C, 51.92; H, 5.81; B, 4.81; N, 6.73; O, 30.74
The following data is based on the product molecular weight 208.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
