PMSA-11 is a novel anti-osteoporosis agent. It targets NFATc1 translocation, blocking the formation of F-action belts and bone resorption in a concentration-dependent manner, exhibiting promising bioactivity, with an IC50 value of 322.9 nM. PMSA-11 was about 15-fold better than PMSA-3-Ac in suppressing osteoclastogenesis in vitro.
MedKoo Cat#: 130583
Name: PMSA-11
CAS#: PMSA-11
Chemical Formula: C22H20N2O3S
Exact Mass: 392.1195
Molecular Weight: 392.47
Elemental Analysis: C, 67.33; H, 5.14; N, 7.14; O, 12.23; S, 8.17
The following data is based on the product molecular weight 392.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
