PMN-41386 is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast. It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 µM, respectively). PMN-41386 is also an oxidative degradation product of apremilast. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).
MedKoo Cat#: 464983
Name: PMN-41386
CAS#: 1384441-38-6
Chemical Formula: C21H22N2O7S
Exact Mass: 446.1148
Molecular Weight: 446.47
Elemental Analysis: C, 56.49; H, 4.97; N, 6.27; O, 25.08; S, 7.18
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 30.0 | 67.19 | ||
| DMSO | 30.0 | 67.19 | ||
| DMSO:PBS (pH 7.2) (1:2) | 0.3 | 0.67 |
The following data is based on the product molecular weight 446.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
