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MedKoo Cat#: 573694 | Name: Ceftezole sodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ceftezole sodium is a broad-spectrum cephalosporin antibiotic active gram-positive and gram-negative bacteria except Pseudomonas aeruginosa, Serratia marcescens and Proteus vulgaris. The bactericidal activity of ceftezole results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Ceftezole has been shown to exhibit potent alpha-glucosidase inhibitory activity.

Chemical Structure

Ceftezole sodium
CAS#41136-22-5 (sodium)

Theoretical Analysis

MedKoo Cat#: 573694

Name: Ceftezole sodium

CAS#: 41136-22-5 (sodium)

Chemical Formula: C13H11N8NaO4S3

Exact Mass: 461.9963

Molecular Weight: 462.45

Elemental Analysis: C, 33.76; H, 2.40; N, 24.23; Na, 4.97; O, 13.84; S, 20.80

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 weeks
50mg USD 550.00 2 Weeks
100mg USD 850.00 2 weeks
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Related CAS #
26973-24-0 (free) 41136-22-5 (sodium)
Synonym
Alomen, Ceftezole sodium, Celoslin, Falomesin
IUPAC/Chemical Name
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 8-oxo-7-((1H-tetrazol-1-ylacetyl)amino)-3-((1,3,4-thiadiazol-2-ylthio)methyl)-, monosodium salt, (6R-trans)-
InChi Key
UGUMHWUOXWFPFH-JHQAJZDGSA-M
InChi Code
1S/C13H12N8O4S3.Na/c22-7(1-20-4-14-18-19-20)16-8-10(23)21-9(12(24)25)6(2-26-11(8)21)3-27-13-17-15-5-28-13;/h4-5,8,11H,1-3H2,(H,16,22)(H,24,25);/q;+1/p-1/t8-,11-;/m1./s1
SMILES Code
[Na+].[O-]C(=O)C1=C(CSc2nncs2)CS[C@@H]3[C@H](NC(=O)Cn4cnnn4)C(=O)N13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 462.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lee DS, Lee JM, Kim SU, Chang KT, Lee SH. Ceftezole, a cephem antibiotic, is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity. Int J Mol Med. 2007 Sep;20(3):379-83. PMID: 17671744. 2: Harada Y, Matsubara S, Kakimoto M, Noto T, Nehashi T. Ceftezole, a new cephalosporin C derivative II. Distribution and excretion in parenteral administration. J Antibiot (Tokyo). 1976 Oct;29(10):1071-82. doi: 10.7164/antibiotics.29.1071. PMID: 994326. 3: Fraschini F, Scaglione F, De Pascale A, Del Mastro S. Pharmacokinetic studies on ceftezole. Chemioterapia. 1986 Dec;5(6):388-90. PMID: 3802300. 4: Noto T, Nehashi T, Endo H, Saito M, Matsubara S. Ceftezole, a new cephalosporin C derivative I. In vitro and in vivo antimicrobial activity. J Antibiot (Tokyo). 1976 Oct;29(10):1058-70. doi: 10.7164/antibiotics.29.1058. PMID: 994325. 5: Cheng X, Huang X, Tian B, Wang T, Hao H. Behaviors and physical mechanism of ceftezole sodium de-agglomeration driven by ultrasound. Ultrason Sonochem. 2021 Jun;74:105570. doi: 10.1016/j.ultsonch.2021.105570. Epub 2021 Apr 20. PMID: 33930689; PMCID: PMC8100626. 6: Nishida M, Murakawa T, Kamimura T, Okada N, Sakamoto H, Fukada S, Nakamoto S, Yokota Y, Miki K. In vitro and in vivo evaluation of ceftezole, a new cephalosporin derivative. Antimicrob Agents Chemother. 1976 Jul;10(1):1-13. doi: 10.1128/AAC.10.1.1. PMID: 825020; PMCID: PMC429680. 7: Ohkawa M, Kuroda K. Pharmacokinetics of ceftezole in patients with normal and impaired renal function. Chemotherapy. 1980;26(4):242-7. doi: 10.1159/000237912. PMID: 7389424. 8: Hu CQ, Cheng SH, Lu L. [Approach to the crystalline characteristics of ceftezole sodium]. Yao Xue Xue Bao. 2002 Apr;37(4):275-9. Chinese. PMID: 12579823. 9: Spreafico P, Scian A, Epis A, Vassen L, Bonazzi C, Lovotti M. Cesarean section: antibiotic prophylaxis with ceftezole. Chemioterapia. 1987 Jun;6(2 Suppl):613-6. PMID: 3334648. 10: Arai S, Takishima T, Kosaka S, Kanazawa T, Takahashi H, Hamajima A, Nishimura H, Yoshida T, Tamura T, Usui Y, Takasugi R, Iwabuchi T, Ise T, Ishii M, Tadokoro K, Matsumoto N, Sato S, Saito K, Sato T, Kudo K, Mori S, Shimanuki K, Ito K, Ishihara T, Maeda T, Tsuiki K, Takahashi K, Kimura H, Saito K, Ishikawa H, Kanehara A. [Studies on the clinical effect of ceftezole (Falomesin 'Chugai') in respiratory- and urinary-tract infections (author's transl)]. Jpn J Antibiot. 1978 Nov;31(11):625-32. Japanese. PMID: 731858. 11: Sawaki M, Narita N, Takezawa Y, Adachi K, Mikami R, Matsuoka Y, Harikane O, Masutani T, Ishii Y, Ohori M, Sakuragi R. [Clinical evaluation of ceftezole (Celoslin) for respiratory infections (author's transl)]. Jpn J Antibiot. 1981 Feb;34(2):188-93. Japanese. PMID: 7253199. 12: Ishikawa K. [Clinical experience with ceftezole (author's transl)]. Jpn J Antibiot. 1978 Nov;31(11):633-5. Japanese. PMID: 731859. 13: Cai Y, Yang L, Shangguan X, Zhao Y, Huang R. Status and Safety Signals of Cephalosporins in Children: A Spontaneous Reporting Database Study. Front Pharmacol. 2021 Oct 20;12:736618. doi: 10.3389/fphar.2021.736618. PMID: 34744720; PMCID: PMC8565806. 14: Chen LE, Shen YZ, Jiang DY, Feng GL, Zhang XL, Wang YF. Amoxicillin and clavulanate potassium in treating children with suppurative tonsillitis. J Biol Regul Homeost Agents. 2017 Jul-Sep,;31(3):625-629. PMID: 28952295. 15: Ishikawa M, Yamamoto Y, Shimizu K, Koh T, Toyoda Y, Shimada J, Sakamoto E, Sumida H, Sakamoto M. [Clinical study on ceftezole in oral surgery. Clinical effect of ceftezole used jointly with gamma-globulin (Gamma-Venin) (author's transl)]. Jpn J Antibiot. 1981 Mar;34(3):404-11. Japanese. PMID: 6169851. 16: Yamaguchi M, Takahashi T, Isoyama K, Johnouchi H, Hanawa H, Yanagisawa N, Yamada K, Ishikawa A, Tomita Y. [Clinical studies of effectiveness of ceftezole (Falomesin 'Chugai') on the infectious disease in infancy and childhood (author's transl)]. Jpn J Antibiot. 1980 Jan;33(1):73-81. Japanese. PMID: 7373851. 17: Akahane K, Furuhama K, Kato M, Une T, Onodera T. Influences of cephem antibiotics on the immune response in mice. Chemotherapy. 1990;36(4):300-7. doi: 10.1159/000238781. PMID: 2123769. 18: Moreo GC, Braschi R, Comaschi GF. Attività terapeutica e tollerabilità del ceftezolo nelle infezioni dell'apparato respiratorio [Therapeutic activity and tolerability of ceftezole in respiratory tract infections]. G Ital Chemioter. 1983 Jan-Apr;30(1):67-70. Italian. PMID: 6662319. 19: Yotsuji A, Mitsuyama J, Hori R, Yasuda T, Saikawa I, Inoue M, Mitsuhashi S. Mechanism of action of cephalosporins and resistance caused by decreased affinity for penicillin-binding proteins in Bacteroides fragilis. Antimicrob Agents Chemother. 1988 Dec;32(12):1848-53. doi: 10.1128/AAC.32.12.1848. PMID: 3266730; PMCID: PMC176031. 20: Hamaguchi H, Minami N, Tanaka I, Iwata Y, Takahashi R, Karitani Y, Izuchi Y. [Treatment of infection in the patients wih hematopoietic malignancy with ceftezole (Falomesin) (author's transl)]. Jpn J Antibiot. 1980 Sep;33(9):959-63. Japanese. PMID: 7218516.