KTX-1001, also known as NSD2 inhibitor 161, is a novel, potent nuclear SET domain-containing protein 2 (NSD2) inhibitor. KTX-1001 selectively targets and binds to NSD2, and inhibits its catalytic activity and the mono- and di-methylation of histone H3 lysine 36 (H3K36). This modulates the expression of genes involved in cellular processes including cellular proliferation, which may lead to decreased growth of cancer cells. NSD2, a member of the NSD family of histone lysine methyltransferase enzymes that catalyzes the mono- and di-methylation of H3K36, is overexpressed and dysregulated in many types of cancers.
MedKoo Cat#: 135711
Name: KTX-1001
CAS#: 2604513-16-6
Chemical Formula: C25H26F4N8O2
Exact Mass: 546.2115
Molecular Weight: 546.53
Elemental Analysis: C, 54.94; H, 4.80; F, 13.90; N, 20.50; O, 5.85
The following data is based on the product molecular weight 546.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
