Synonym
Norfluoxetine (oxalate); Norfluoxetine oxalate; Norfluoxetine; Desmethylfluoxetine
IUPAC/Chemical Name
3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine oxalate
InChi Key
FDWJCEPFCGIDPF-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H16F3NO.C2H2O4/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;3-1(4)2(5)6/h1-9,15H,10-11,20H2;(H,3,4)(H,5,6)
SMILES Code
OC(C(O)=O)=O.NCCC(C1=CC=CC=C1)OC2=CC=C(C(F)(F)F)C=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
385.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Dhami KS, Churchward MA, Baker GB, Todd KG. Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis. J Neurochem. 2019 Mar;148(6):761-778. doi: 10.1111/jnc.14661. Epub 2019 Feb 12. PMID: 30613984.
3: Rodrigues P, Cunha V, Oliva-Teles L, Ferreira M, Guimarães L. Effects of norfluoxetine and venlafaxine in zebrafish larvae: Molecular data. Data Brief. 2020 Nov 10;33:106515. doi: 10.1016/j.dib.2020.106515. PMID: 33294513; PMCID: PMC7689041.
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6: Rodrigues P, Cunha V, Oliva-Teles L, Ferreira M, Guimarães L. Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment. J Hazard Mater. 2020 Dec 5;400:123171. doi: 10.1016/j.jhazmat.2020.123171. Epub 2020 Jun 17. PMID: 32593945.
7: Hiemke C, Härtter S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacol Ther. 2000 Jan;85(1):11-28. doi: 10.1016/s0163-7258(99)00048-0. PMID: 10674711.
8: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Fluoxetine. 2021 Feb 15. PMID: 30000245.
9: Zindler F, Tisler S, Loerracher AK, Zwiener C, Braunbeck T. Norfluoxetine Is the Only Metabolite of Fluoxetine in Zebrafish (Danio rerio) Embryos That Accumulates at Environmentally Relevant Exposure Scenarios. Environ Sci Technol. 2020 Apr 7;54(7):4200-4209. doi: 10.1021/acs.est.9b07618. Epub 2020 Mar 13. PMID: 32167300.
10: Kim KI, Chung YC, Jin BK. Norfluoxetine Prevents Degeneration of Dopamine Neurons by Inhibiting Microglia-Derived Oxidative Stress in an MPTP Mouse Model of Parkinson's Disease. Mediators Inflamm. 2018 Dec 30;2018:4591289. doi: 10.1155/2018/4591289. PMID: 30692871; PMCID: PMC6332876.
