ITYR-DBRMD | CAS#unknown | DIO3 inhibitor

MedKoo Cat#: 465988 | Name: ITYR-DBRMD

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ITYR-DBRMD is removed for commercial reasons.

Chemical Structure

ITYR-DBRMD

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465988

Name: ITYR-DBRMD

CAS#: unknown

Chemical Formula: C13H7Br2I2NO5

Exact Mass: 668.6780

Molecular Weight: 670.82

Elemental Analysis: C, 23.28; H, 1.05; Br, 23.82; I, 37.84; N, 2.09; O, 11.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ITYR-DBRMD; ITYRDBRMD; ITYR DBRMD;

IUPAC/Chemical Name

2-(3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid

InChi Key

RRUKHORYJGQCPT-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H7Br2I2NO5/c14-8-9(15)12(21)18(11(8)20)7(13(22)23)3-4-1-5(16)10(19)6(17)2-4/h1-2,7,19H,3H2,(H,22,23)

SMILES Code

O=C(O)C(N1C(C(Br)=C(Br)C1=O)=O)CC2=CC(I)=C(O)C(I)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 670.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Moskovich D, Finkelshtein Y, Alfandari A, Rosemarin A, Lifschytz T, Weisz A, Mondal S, Ungati H, Katzav A, Kidron D, Mugesh G, Ellis M, Lerer B, Ashur-Fabian O. Targeting the DIO3 enzyme using first-in-class inhibitors effectively suppresses tumor growth: a new paradigm in ovarian cancer treatment. Oncogene. 2021 Nov;40(44):6248-6257. doi: 10.1038/s41388-021-02020-z. Epub 2021 Sep 23. PMID: 34556811.