JAK/HDAC inhibitor 21 | CAS# | JAK/HDAC inhibitor

MedKoo Cat#: 130499 | Name: JAK/HDAC inhibitor 21

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JAK/HDAC inhibitor 21 is a HDAC3/6 and JAK1/2 inhibitor. It is selective for JAK2, presenting antiproliferative activity in both hematological malignancies and solid cancers.

Chemical Structure

JAK/HDAC inhibitor 21

CAS#JAK/HDAC inhibitor 21

Theoretical Analysis

MedKoo Cat#: 130499

Name: JAK/HDAC inhibitor 21

CAS#: JAK/HDAC inhibitor 21

Chemical Formula: C30H42N6O5S

Exact Mass: 598.2937

Molecular Weight: 598.76

Elemental Analysis: C, 60.18; H, 7.07; N, 14.04; O, 13.36; S, 5.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

JAK/HDAC inhibitor-21, JAK/HDAC-In-21, JAK/HDAC In-21, JAK/HDAC In 21

IUPAC/Chemical Name

7-(4-((4-((3-(N-(tert-Butyl)sulfamoyl)phenyl)amino)-5-methylpyrimidin-2-yl)amino)phenoxy)-N-hydroxyheptanamide

InChi Key

YJVWRVUQZNYKON-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H38N6O5S/c1-20-19-29-27(31-21-13-15-23(16-14-21)39-17-8-6-5-7-12-25(35)33-36)32-26(20)30-22-10-9-11-24(18-22)40(37,38)34-28(2,3)4/h9-11,13-16,18-19,34,36H,5-8,12,17H2,1-4H3,(H,33,35)(H2,29,30,31,32)

SMILES Code

CC(C(NC1=CC=CC(S(NC(C)(C)C)(=O)=O)=C1)=N2)=CN=C2NC3=CC=C(OCCCCCCC(NO)=O)C=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 598.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Qiu Q, Chi F, Zhou D, Xie Z, Liu Y, Wu H, Yin Z, Shi W, Qian H. Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers. J Med Chem. 2023 Apr 27;66(8):5753-5773. doi: 10.1021/acs.jmedchem.3c00036. Epub 2023 Apr 14. PMID: 37057760.