Quazodine | CAS#4015-32-1 | inhibitor

MedKoo Cat#: 584718 | Name: Quazodine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quazodine is a phosphodiesterase inhibitor.

Chemical Structure

Quazodine

CAS#4015-32-1

Theoretical Analysis

MedKoo Cat#: 584718

Name: Quazodine

CAS#: 4015-32-1

Chemical Formula: C12H14N2O2

Exact Mass: 218.1055

Molecular Weight: 218.26

Elemental Analysis: C, 66.04; H, 6.47; N, 12.84; O, 14.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Quazodine; MJ 1988

IUPAC/Chemical Name

6,7-Dimethoxy-4-ethylquinazoline

InChi Key

STAYVYIMUXVGBN-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H14N2O2/c1-4-9-8-5-11(15-2)12(16-3)6-10(8)14-7-13-9/h5-7H,4H2,1-3H3

SMILES Code

CCC1=C2C=C(OC)C(OC)=CC2=NC=N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 218.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Parratt JR, Winslow E. Actions of quazodine (MJ1988) on smooth muscle. Br J Pharmacol. 1971 Nov;43(3):612-23. PubMed PMID: 4333696; PubMed Central PMCID: PMC1665786. 2: Parratt JR, Winslow E. Cardiovascular pharmacology of quazodine (MJ-1988), with particular reference to effects of myocardial blood flow and metabolic heat production. Br J Pharmacol. 1971 Jun;42(2):193-204. PubMed PMID: 4397441; PubMed Central PMCID: PMC1667164. 3: Parratt JR, Winslow E. Haemodynamic and coronary effects of quazodine in cats with developing myocardial infarcts. J Pharm Pharmacol. 1972 Sep;24(9):673-80. PubMed PMID: 4404069. 4: Kane KA, Morcillo-Sanchez EJ, Parratt JR, Rodger IW, Shahid M. The relationship between coronary artery occlusion-induced arrhythmias and myocardial cyclic nucleotide levels in the anaesthetized rat. Br J Pharmacol. 1985 Jan;84(1):139-45. PubMed PMID: 2579698; PubMed Central PMCID: PMC1987211. 5: Amer MS, Browder HP. Effect of quazodine on phosphodiesterase. Proc Soc Exp Biol Med. 1971 Mar;136(3):750-2. PubMed PMID: 4324513. 6: Gomoll AW, Byrne JE, McKinney GR. Interactions of quazodine with cardiotoxic doses of ouabain in the anesthetized dog. Arch Int Pharmacodyn Ther. 1974 Jan;207(1):16-27. PubMed PMID: 4151046. 7: Bowman WC, Khan HH, Savage AO. Some antagonists of dantrolene sodium on the isolated diaphragm muscle of the rat. J Pharm Pharmacol. 1977 Oct;29(10):616-25. PubMed PMID: 21242. 8: Bartek MJ, LaBudde JA. Metabolism of (14C)-quazodine in the rat, dog, and man. Toxicol Appl Pharmacol. 1976 May;36(2):307-22. PubMed PMID: 1273849. 9: Nott MW, Winslow E. Effects of quazodine (MJ 1988) on contractions of the isolated hemidiaphragm of the rat and the biventer cervicis muscle of the chick. Br J Pharmacol. 1973 Jul;48(3):409-17. PubMed PMID: 4764289; PubMed Central PMCID: PMC1776117. 10: Nott MW, Winslow E. Proceedings: Effects of quazodine on cat fast- and slow-contracting skeletal muscles. Br J Pharmacol. 1974 Mar;50(3):470P-471P. PubMed PMID: 4853813; PubMed Central PMCID: PMC1776710. 11: Parratt JR, Winslow E. The effects of quazodine on myocardial blood flow in developing myocardial infarcts. J Pharm Pharmacol. 1971 Dec;23:224S-225S. PubMed PMID: 4401475. 12: Parratt JR, Winslow E. The haemodynamic effects of quazodine, a cardiac stimulant, in experimental E. coli endotoxin shock in the cat. Clin Exp Pharmacol Physiol. 1974 Jan-Feb;1(1):31-41. PubMed PMID: 4616780. 13: Friedman Y, Lang M, Burke G. Further characterization of bovine thyroid prostaglandin synthase. Biochim Biophys Acta. 1975 Aug 26;397(2):331-41. PubMed PMID: 168923. 14: Greenslade FC, Scott CK, Newquist KL, Krider KM, Chasin M. Heterogeneity of biochemical actions among vasodilators. J Pharm Sci. 1982 Jan;71(1):94-100. PubMed PMID: 6276530. 15: Burke G, Chang LL, Szabo M. Thyrotropin and cyclic nucleotide effects on prostaglandin levels in isolated thyroid cells. Science. 1973 May 25;180(4088):872-5. PubMed PMID: 4350404.