MedKoo Cat#: 130465 | Name: JSD26

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JSD26 is an inhibitor of SCoR2 with high selectivity over AKR1B1 (10-fold) for use in the treatment of acute kidney injury.

Chemical Structure

JSD26
JSD26
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130465

Name: JSD26

CAS#: N/A

Chemical Formula: C18H14N2O2

Exact Mass: 290.1055

Molecular Weight: 290.32

Elemental Analysis: C, 74.47; H, 4.86; N, 9.65; O, 11.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JSD26
IUPAC/Chemical Name
(S)-2-cyclopropylspiro[fluorene-9,4'-imidazolidine]-2',5'-dione
InChi Key
YNIGFZOTWOVBHD-SFHVURJKSA-N
InChi Code
InChI=1S/C18H14N2O2/c21-16-18(20-17(22)19-16)14-4-2-1-3-12(14)13-8-7-11(9-15(13)18)10-5-6-10/h1-4,7-10H,5-6H2,(H2,19,20,21,22)/t18-/m0/s1
SMILES Code
O=C(N1)NC([C@@]21C3=C(C4=C2C=CC=C4)C=CC(C5CC5)=C3)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 290.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Zhou HL, Hausladen A, Anand P, Rajavel M, Stomberski CT, Zhang R, Premont RT, Greenlee WJ, van den Akker F, Stamler JS. Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury. J Med Chem. 2023 Apr 7. doi: 10.1021/acs.jmedchem.2c02089. Epub ahead of print. PMID: 37027003.